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Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions

Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanis...

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Detalles Bibliográficos
Autores principales:	Blus, Bartlomiej Jan, Koh, Junseock, Krolak, Aleksandra, Seo, Hyuk-Soo, Coutavas, Elias, Blobel, Günter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881172/ https://www.ncbi.nlm.nih.gov/pubmed/31807700 http://dx.doi.org/10.1126/sciadv.aax1836

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