JMJD3 in the regulation of human diseases

In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3)...

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Detalles Bibliográficos
Autores principales: Zhang, Xiangxian, Liu, Li, Yuan, Xia, Wei, Yuquan, Wei, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881266/
https://www.ncbi.nlm.nih.gov/pubmed/31701394
http://dx.doi.org/10.1007/s13238-019-0653-9
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author Zhang, Xiangxian
Liu, Li
Yuan, Xia
Wei, Yuquan
Wei, Xiawei
author_facet Zhang, Xiangxian
Liu, Li
Yuan, Xia
Wei, Yuquan
Wei, Xiawei
author_sort Zhang, Xiangxian
collection PubMed
description In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
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spelling pubmed-68812662019-12-10 JMJD3 in the regulation of human diseases Zhang, Xiangxian Liu, Li Yuan, Xia Wei, Yuquan Wei, Xiawei Protein Cell Review In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review. Higher Education Press 2019-11-07 2019-12 /pmc/articles/PMC6881266/ /pubmed/31701394 http://dx.doi.org/10.1007/s13238-019-0653-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Zhang, Xiangxian
Liu, Li
Yuan, Xia
Wei, Yuquan
Wei, Xiawei
JMJD3 in the regulation of human diseases
title JMJD3 in the regulation of human diseases
title_full JMJD3 in the regulation of human diseases
title_fullStr JMJD3 in the regulation of human diseases
title_full_unstemmed JMJD3 in the regulation of human diseases
title_short JMJD3 in the regulation of human diseases
title_sort jmjd3 in the regulation of human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881266/
https://www.ncbi.nlm.nih.gov/pubmed/31701394
http://dx.doi.org/10.1007/s13238-019-0653-9
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