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Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron

Microbeam Radiation Therapy (MRT) is an emerging cancer treatment modality characterised by the use of high-intensity synchrotron-generated x-rays, spatially fractionated by a multi-slit collimator (MSC), to ablate target tumours. The implementation of an accurate treatment planning system, coupled...

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Autores principales: Dipuglia, Andrew, Cameron, Matthew, Davis, Jeremy A., Cornelius, Iwan M., Stevenson, Andrew W., Rosenfeld, Anatoly B., Petasecca, Marco, Corde, Stéphanie, Guatelli, Susanna, Lerch, Michael L. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881291/
https://www.ncbi.nlm.nih.gov/pubmed/31776395
http://dx.doi.org/10.1038/s41598-019-53991-9
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author Dipuglia, Andrew
Cameron, Matthew
Davis, Jeremy A.
Cornelius, Iwan M.
Stevenson, Andrew W.
Rosenfeld, Anatoly B.
Petasecca, Marco
Corde, Stéphanie
Guatelli, Susanna
Lerch, Michael L. F.
author_facet Dipuglia, Andrew
Cameron, Matthew
Davis, Jeremy A.
Cornelius, Iwan M.
Stevenson, Andrew W.
Rosenfeld, Anatoly B.
Petasecca, Marco
Corde, Stéphanie
Guatelli, Susanna
Lerch, Michael L. F.
author_sort Dipuglia, Andrew
collection PubMed
description Microbeam Radiation Therapy (MRT) is an emerging cancer treatment modality characterised by the use of high-intensity synchrotron-generated x-rays, spatially fractionated by a multi-slit collimator (MSC), to ablate target tumours. The implementation of an accurate treatment planning system, coupled with simulation tools that allow for independent verification of calculated dose distributions are required to ensure optimal treatment outcomes via reliable dose delivery. In this article we present data from the first Geant4 Monte Carlo radiation transport model of the Imaging and Medical Beamline at the Australian Synchrotron. We have developed the model for use as an independent verification tool for experiments in one of three MRT delivery rooms and therefore compare simulation results with equivalent experimental data. The normalised x-ray spectra produced by the Geant4 model and a previously validated analytical model, SPEC, showed very good agreement using wiggler magnetic field strengths of 2 and 3 T. However, the validity of absolute photon flux at the plane of the Phase Space File (PSF) for a fixed number of simulated electrons was unable to be established. This work shows a possible limitation of the G4SynchrotronRadiation process to model synchrotron radiation when using a variable magnetic field. To account for this limitation, experimentally derived normalisation factors for each wiggler field strength determined under reference conditions were implemented. Experimentally measured broadbeam and microbeam dose distributions within a Gammex RMI457 Solid Water(®) phantom were compared to simulated distributions generated by the Geant4 model. Simulated and measured broadbeam dose distributions agreed within 3% for all investigated configurations and measured depths. Agreement between the simulated and measured microbeam dose distributions agreed within 5% for all investigated configurations and measured depths.
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spelling pubmed-68812912019-12-05 Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron Dipuglia, Andrew Cameron, Matthew Davis, Jeremy A. Cornelius, Iwan M. Stevenson, Andrew W. Rosenfeld, Anatoly B. Petasecca, Marco Corde, Stéphanie Guatelli, Susanna Lerch, Michael L. F. Sci Rep Article Microbeam Radiation Therapy (MRT) is an emerging cancer treatment modality characterised by the use of high-intensity synchrotron-generated x-rays, spatially fractionated by a multi-slit collimator (MSC), to ablate target tumours. The implementation of an accurate treatment planning system, coupled with simulation tools that allow for independent verification of calculated dose distributions are required to ensure optimal treatment outcomes via reliable dose delivery. In this article we present data from the first Geant4 Monte Carlo radiation transport model of the Imaging and Medical Beamline at the Australian Synchrotron. We have developed the model for use as an independent verification tool for experiments in one of three MRT delivery rooms and therefore compare simulation results with equivalent experimental data. The normalised x-ray spectra produced by the Geant4 model and a previously validated analytical model, SPEC, showed very good agreement using wiggler magnetic field strengths of 2 and 3 T. However, the validity of absolute photon flux at the plane of the Phase Space File (PSF) for a fixed number of simulated electrons was unable to be established. This work shows a possible limitation of the G4SynchrotronRadiation process to model synchrotron radiation when using a variable magnetic field. To account for this limitation, experimentally derived normalisation factors for each wiggler field strength determined under reference conditions were implemented. Experimentally measured broadbeam and microbeam dose distributions within a Gammex RMI457 Solid Water(®) phantom were compared to simulated distributions generated by the Geant4 model. Simulated and measured broadbeam dose distributions agreed within 3% for all investigated configurations and measured depths. Agreement between the simulated and measured microbeam dose distributions agreed within 5% for all investigated configurations and measured depths. Nature Publishing Group UK 2019-11-27 /pmc/articles/PMC6881291/ /pubmed/31776395 http://dx.doi.org/10.1038/s41598-019-53991-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dipuglia, Andrew
Cameron, Matthew
Davis, Jeremy A.
Cornelius, Iwan M.
Stevenson, Andrew W.
Rosenfeld, Anatoly B.
Petasecca, Marco
Corde, Stéphanie
Guatelli, Susanna
Lerch, Michael L. F.
Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title_full Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title_fullStr Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title_full_unstemmed Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title_short Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron
title_sort validation of a monte carlo simulation for microbeam radiation therapy on the imaging and medical beamline at the australian synchrotron
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881291/
https://www.ncbi.nlm.nih.gov/pubmed/31776395
http://dx.doi.org/10.1038/s41598-019-53991-9
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