Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors

A major hallmark of Parkinson's disease is loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The pathophysiological mechanisms causing this relatively selective neurodegeneration are poorly understood, and thus experimental systems allowing to study dopaminergic neuron...

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Detalles Bibliográficos
Autores principales: Mahajani, Sameehan, Raina, Anupam, Fokken, Claudia, Kügler, Sebastian, Bähr, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881336/
https://www.ncbi.nlm.nih.gov/pubmed/31776327
http://dx.doi.org/10.1038/s41419-019-2133-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881336/
https://www.ncbi.nlm.nih.gov/pubmed/31776327
http://dx.doi.org/10.1038/s41419-019-2133-9

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