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Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes
To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881342/ https://www.ncbi.nlm.nih.gov/pubmed/31776421 http://dx.doi.org/10.1038/s41598-019-54164-4 |
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author | López-Tinoco, Cristina Jiménez-Blázquez, José Luis Larrán-Escandón, Laura Roca-Rodríguez, María del Mar Bugatto, Fernando Aguilar-Diosdado, Manuel |
author_facet | López-Tinoco, Cristina Jiménez-Blázquez, José Luis Larrán-Escandón, Laura Roca-Rodríguez, María del Mar Bugatto, Fernando Aguilar-Diosdado, Manuel |
author_sort | López-Tinoco, Cristina |
collection | PubMed |
description | To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neutral Protamine Hagedorn insulin and short-acting insulin analogues; 19% with premixed human insulin; 40.1% with insulin glargine and lispro, 6.2% with detemir and aspart and 20% with continuous subcutaneous insulin infusion. All 5 types of treatment achieved a reduction of the mean HbA1c during pregnancy (p = 0.01). Pre-pregnancy care was carried out for 48% of patients. We found no statistically significant differences between the different insulin therapies and the obstetric-fetal outcomes. In conclusión, the different insulin therapies used in patients with pregestational diabetes mellitus does not seem to affect obstetric-fetal outcomes. |
format | Online Article Text |
id | pubmed-6881342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68813422019-12-06 Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes López-Tinoco, Cristina Jiménez-Blázquez, José Luis Larrán-Escandón, Laura Roca-Rodríguez, María del Mar Bugatto, Fernando Aguilar-Diosdado, Manuel Sci Rep Article To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neutral Protamine Hagedorn insulin and short-acting insulin analogues; 19% with premixed human insulin; 40.1% with insulin glargine and lispro, 6.2% with detemir and aspart and 20% with continuous subcutaneous insulin infusion. All 5 types of treatment achieved a reduction of the mean HbA1c during pregnancy (p = 0.01). Pre-pregnancy care was carried out for 48% of patients. We found no statistically significant differences between the different insulin therapies and the obstetric-fetal outcomes. In conclusión, the different insulin therapies used in patients with pregestational diabetes mellitus does not seem to affect obstetric-fetal outcomes. Nature Publishing Group UK 2019-11-27 /pmc/articles/PMC6881342/ /pubmed/31776421 http://dx.doi.org/10.1038/s41598-019-54164-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article López-Tinoco, Cristina Jiménez-Blázquez, José Luis Larrán-Escandón, Laura Roca-Rodríguez, María del Mar Bugatto, Fernando Aguilar-Diosdado, Manuel Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title | Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title_full | Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title_fullStr | Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title_full_unstemmed | Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title_short | Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes |
title_sort | effect of different insulin therapies on obstetric-fetal outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881342/ https://www.ncbi.nlm.nih.gov/pubmed/31776421 http://dx.doi.org/10.1038/s41598-019-54164-4 |
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