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Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease

BACKGROUND: Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of non-alcoholic fatty liver disease (NAFLD). Polygonatum kingianum (PK) has been traditionally used in China as a medicinal and nutritional...

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Autores principales: Yang, Xing-Xin, Wei, Jia-Di, Mu, Jian-Kang, Liu, Xin, Li, Feng-Jiao, Li, Yan-Qin, Gu, Wen, Li, Jing-Ping, Yu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881506/
https://www.ncbi.nlm.nih.gov/pubmed/31798277
http://dx.doi.org/10.3748/wjg.v25.i43.6404
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author Yang, Xing-Xin
Wei, Jia-Di
Mu, Jian-Kang
Liu, Xin
Li, Feng-Jiao
Li, Yan-Qin
Gu, Wen
Li, Jing-Ping
Yu, Jie
author_facet Yang, Xing-Xin
Wei, Jia-Di
Mu, Jian-Kang
Liu, Xin
Li, Feng-Jiao
Li, Yan-Qin
Gu, Wen
Li, Jing-Ping
Yu, Jie
author_sort Yang, Xing-Xin
collection PubMed
description BACKGROUND: Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of non-alcoholic fatty liver disease (NAFLD). Polygonatum kingianum (PK) has been traditionally used in China as a medicinal and nutritional ingredient for centuries and can alleviate high-fat diet (HFD)-induced NAFLD by promoting mitochondrial functions. To date, the underlying molecular mechanism of PK for treating mitochondrial dysfunctions and thus alleviating NAFLD remains unclear. AIM: To identify the molecular mechanism behind the mitochondrial regulatory action of PK against HFD-induced NAFLD in rats. METHODS: NAFLD model was induced in rats with HFD. The rats were intragastrically administered PK (4 g/kg per day) for 14 wk. Metabolites in hepatic mitochondrial samples were profiled through ultra-high performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to find the potential biomarkers and metabolic pathways. RESULTS: PK significantly restored the metabolites’ levels in the mitochondrial samples. Ten potential biomarkers were identified in the analyzed samples. These biomarkers are involved in riboflavin metabolism. CONCLUSION: PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial functions. Thus, PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases.
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spelling pubmed-68815062019-12-03 Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease Yang, Xing-Xin Wei, Jia-Di Mu, Jian-Kang Liu, Xin Li, Feng-Jiao Li, Yan-Qin Gu, Wen Li, Jing-Ping Yu, Jie World J Gastroenterol Basic Study BACKGROUND: Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of non-alcoholic fatty liver disease (NAFLD). Polygonatum kingianum (PK) has been traditionally used in China as a medicinal and nutritional ingredient for centuries and can alleviate high-fat diet (HFD)-induced NAFLD by promoting mitochondrial functions. To date, the underlying molecular mechanism of PK for treating mitochondrial dysfunctions and thus alleviating NAFLD remains unclear. AIM: To identify the molecular mechanism behind the mitochondrial regulatory action of PK against HFD-induced NAFLD in rats. METHODS: NAFLD model was induced in rats with HFD. The rats were intragastrically administered PK (4 g/kg per day) for 14 wk. Metabolites in hepatic mitochondrial samples were profiled through ultra-high performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to find the potential biomarkers and metabolic pathways. RESULTS: PK significantly restored the metabolites’ levels in the mitochondrial samples. Ten potential biomarkers were identified in the analyzed samples. These biomarkers are involved in riboflavin metabolism. CONCLUSION: PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial functions. Thus, PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases. Baishideng Publishing Group Inc 2019-11-21 2019-11-21 /pmc/articles/PMC6881506/ /pubmed/31798277 http://dx.doi.org/10.3748/wjg.v25.i43.6404 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Basic Study
Yang, Xing-Xin
Wei, Jia-Di
Mu, Jian-Kang
Liu, Xin
Li, Feng-Jiao
Li, Yan-Qin
Gu, Wen
Li, Jing-Ping
Yu, Jie
Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title_full Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title_fullStr Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title_full_unstemmed Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title_short Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
title_sort mitochondrial metabolomic profiling for elucidating the alleviating potential of polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881506/
https://www.ncbi.nlm.nih.gov/pubmed/31798277
http://dx.doi.org/10.3748/wjg.v25.i43.6404
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