Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia

Somatic mutations of DNMT3A occur in about 20% of acute myeloid leukemia (AML) patients. They mostly consist in heterozygous missense mutations targeting a hotspot site at R882 codon, which exhibit a dominant negative effect and are associated with high myeloblast count, advanced age, and poor progn...

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Detalles Bibliográficos
Autores principales: Bruno, Samantha, Bochicchio, Maria Teresa, Franchini, Eugenia, Padella, Antonella, Marconi, Giovanni, Ghelli Luserna di Rorà, Andrea, Venturi, Claudia, Raffini, Maddalena, Prisinzano, Giovanna, Ferrari, Anna, Bandini, Lorenza, Robustelli, Valentina, Pazzaglia, Martina, Fontana, Maria Chiara, Sartor, Chiara, Abbenante, Maria Chiara, Papayannidis, Cristina, Soverini, Simona, Ottaviani, Emanuela, Simonetti, Giorgia, Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881567/
https://www.ncbi.nlm.nih.gov/pubmed/31827512
http://dx.doi.org/10.1155/2019/5985923

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