miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

miR-221 is regarded as an oncogene in many malignancies, and miR-221-mediated resistance towards TRAIL was one of the first oncogenic roles shown for this small noncoding RNA. In contrast, miR-221 is downregulated in prostate cancer (PCa), thereby implying a tumour suppressive function. By using pro...

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Detalles Bibliográficos
Autores principales: Krebs, Markus, Behrmann, Christoph, Kalogirou, Charis, Sokolakis, Ioannis, Kneitz, Susanne, Kruithof-de Julio, Marianna, Zoni, Eugenio, Rech, Anne, Schilling, Bastian, Kübler, Hubert, Spahn, Martin, Kneitz, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881584/
https://www.ncbi.nlm.nih.gov/pubmed/31828111
http://dx.doi.org/10.1155/2019/6392748

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