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Selection of an Efficient AAV Vector for Robust CNS Transgene Expression

Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection of transgene expression. After only two selection r...

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Detalles Bibliográficos
Autores principales:	Hanlon, Killian S., Meltzer, Jonah C., Buzhdygan, Tetyana, Cheng, Ming J., Sena-Esteves, Miguel, Bennett, Rachel E., Sullivan, Timothy P., Razmpour, Roshanak, Gong, Yi, Ng, Carrie, Nammour, Josette, Maiz, Daniela, Dujardin, Simon, Ramirez, Servio H., Hudry, Eloise, Maguire, Casey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881693/ https://www.ncbi.nlm.nih.gov/pubmed/31788496 http://dx.doi.org/10.1016/j.omtm.2019.10.007

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