Cargando…

Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session

During the neonatal period, the brain is susceptible to external influences. Exposure to stressful events during this phase of life influences brain development and impacts adult life. In animals, the maternal deprivation (MD) model is effective in mimicking stress in the early stages of development...

Descripción completa

Detalles Bibliográficos
Autores principales: Sosa, Priscila Marques, Neves, Ben-Hur S., Carrazoni, Guilherme Salgado, Gomes, Gabriela Mendes, Del Rosso, Gabriel, Ramborger, Bruna Piaia, Rohers, Rafael, Mello-Carpes, Pâmela Billig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881746/
https://www.ncbi.nlm.nih.gov/pubmed/31827496
http://dx.doi.org/10.1155/2019/3608502
_version_ 1783474006769270784
author Sosa, Priscila Marques
Neves, Ben-Hur S.
Carrazoni, Guilherme Salgado
Gomes, Gabriela Mendes
Del Rosso, Gabriel
Ramborger, Bruna Piaia
Rohers, Rafael
Mello-Carpes, Pâmela Billig
author_facet Sosa, Priscila Marques
Neves, Ben-Hur S.
Carrazoni, Guilherme Salgado
Gomes, Gabriela Mendes
Del Rosso, Gabriel
Ramborger, Bruna Piaia
Rohers, Rafael
Mello-Carpes, Pâmela Billig
author_sort Sosa, Priscila Marques
collection PubMed
description During the neonatal period, the brain is susceptible to external influences. Exposure to stressful events during this phase of life influences brain development and impacts adult life. In animals, the maternal deprivation (MD) model is effective in mimicking stress in the early stages of development. In contrast, physical exercise seems to be able to prevent deficits in memory consolidation. Although the effects of chronic exercise in cognition are already well established, little is known about the effects of acute aerobic exercise. Here, male Wistar rats divided into deprived (MD) and nondeprived (NMD) rats were submitted to the object recognition (OR) memory test. Immediately after OR training, some of the rats were submitted to a single aerobic exercise session for 30 minutes. Memory consolidation and persistence were evaluated by retention tests performed 24 h and 7, 14, and 21 days after OR training. We show that a single physical exercise session is able to modulate learning by promoting memory consolidation and persistence in rats with cognitive deficits induced by MD. Hippocampal dopamine levels, measured by HPLC, were not altered after OR training in rats that performed and in rats that did not perform an exercise session; on the other hand, while OR training promoted increase of hippocampal norepinephrine in NMD rats, the MD rats did not present this increase, regardless of the practice or not of exercise.
format Online
Article
Text
id pubmed-6881746
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-68817462019-12-11 Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session Sosa, Priscila Marques Neves, Ben-Hur S. Carrazoni, Guilherme Salgado Gomes, Gabriela Mendes Del Rosso, Gabriel Ramborger, Bruna Piaia Rohers, Rafael Mello-Carpes, Pâmela Billig Neural Plast Research Article During the neonatal period, the brain is susceptible to external influences. Exposure to stressful events during this phase of life influences brain development and impacts adult life. In animals, the maternal deprivation (MD) model is effective in mimicking stress in the early stages of development. In contrast, physical exercise seems to be able to prevent deficits in memory consolidation. Although the effects of chronic exercise in cognition are already well established, little is known about the effects of acute aerobic exercise. Here, male Wistar rats divided into deprived (MD) and nondeprived (NMD) rats were submitted to the object recognition (OR) memory test. Immediately after OR training, some of the rats were submitted to a single aerobic exercise session for 30 minutes. Memory consolidation and persistence were evaluated by retention tests performed 24 h and 7, 14, and 21 days after OR training. We show that a single physical exercise session is able to modulate learning by promoting memory consolidation and persistence in rats with cognitive deficits induced by MD. Hippocampal dopamine levels, measured by HPLC, were not altered after OR training in rats that performed and in rats that did not perform an exercise session; on the other hand, while OR training promoted increase of hippocampal norepinephrine in NMD rats, the MD rats did not present this increase, regardless of the practice or not of exercise. Hindawi 2019-11-16 /pmc/articles/PMC6881746/ /pubmed/31827496 http://dx.doi.org/10.1155/2019/3608502 Text en Copyright © 2019 Priscila Marques Sosa et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sosa, Priscila Marques
Neves, Ben-Hur S.
Carrazoni, Guilherme Salgado
Gomes, Gabriela Mendes
Del Rosso, Gabriel
Ramborger, Bruna Piaia
Rohers, Rafael
Mello-Carpes, Pâmela Billig
Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title_full Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title_fullStr Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title_full_unstemmed Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title_short Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session
title_sort maternal deprivation induces memory deficits that are reduced by one aerobic exercise shot performed after the learning session
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881746/
https://www.ncbi.nlm.nih.gov/pubmed/31827496
http://dx.doi.org/10.1155/2019/3608502
work_keys_str_mv AT sosapriscilamarques maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT nevesbenhurs maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT carrazoniguilhermesalgado maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT gomesgabrielamendes maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT delrossogabriel maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT ramborgerbrunapiaia maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT rohersrafael maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession
AT mellocarpespamelabillig maternaldeprivationinducesmemorydeficitsthatarereducedbyoneaerobicexerciseshotperformedafterthelearningsession