Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma

AIM/OBJECTIVES: To evaluate serum levels of Alpha-1 antitrypsin in patients with oral squamous cell carcinoma and compare them with that of healthy subjects with and without tobacco habits. MATERIALS AND METHOD: The sample of 83 subjects was divided into three groups: 30 subjects with oral squamous...

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Autores principales: Ahuja, Upasana S., Puri, Nidhi, Bagewadi, Anjana, Keluskar, Vaishali, Ahuja, Anshuman, Singh, Harkanwal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881917/
https://www.ncbi.nlm.nih.gov/pubmed/31803669
http://dx.doi.org/10.4103/jfmpc.jfmpc_571_19
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author Ahuja, Upasana S.
Puri, Nidhi
Bagewadi, Anjana
Keluskar, Vaishali
Ahuja, Anshuman
Singh, Harkanwal P.
author_facet Ahuja, Upasana S.
Puri, Nidhi
Bagewadi, Anjana
Keluskar, Vaishali
Ahuja, Anshuman
Singh, Harkanwal P.
author_sort Ahuja, Upasana S.
collection PubMed
description AIM/OBJECTIVES: To evaluate serum levels of Alpha-1 antitrypsin in patients with oral squamous cell carcinoma and compare them with that of healthy subjects with and without tobacco habits. MATERIALS AND METHOD: The sample of 83 subjects was divided into three groups: 30 subjects with oral squamous cell carcinoma formed Group A. The age, sex, habit matched 23 healthy subjects with tobacco habit formed Group B and 30 healthy without history of consumption of tobacco formed Group C. Analysis of the samples was done using Alpha 1 antitrypsin kit and spectrophotometer. RESULTS: There was a 2.33-fold rise in serum levels of Alpha 1 antitrypsin in Group A compared to Group B, 3.71-fold rise in Group A compared to Group C and 1.59-fold rise in Group B compared to Group C (P < 0.001). A definite rise in serum Alpha 1 antitrypsin levels in patients with oral squamous cell carcinoma as compared with healthy subjects with and without tobacco habits was observed. CONCLUSION: Alpha1-antitrypsin can be used as an adjunct to various diagnostic procedures implied for the evaluation of oral squamous cell carcinoma.
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spelling pubmed-68819172019-12-04 Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma Ahuja, Upasana S. Puri, Nidhi Bagewadi, Anjana Keluskar, Vaishali Ahuja, Anshuman Singh, Harkanwal P. J Family Med Prim Care Original Article AIM/OBJECTIVES: To evaluate serum levels of Alpha-1 antitrypsin in patients with oral squamous cell carcinoma and compare them with that of healthy subjects with and without tobacco habits. MATERIALS AND METHOD: The sample of 83 subjects was divided into three groups: 30 subjects with oral squamous cell carcinoma formed Group A. The age, sex, habit matched 23 healthy subjects with tobacco habit formed Group B and 30 healthy without history of consumption of tobacco formed Group C. Analysis of the samples was done using Alpha 1 antitrypsin kit and spectrophotometer. RESULTS: There was a 2.33-fold rise in serum levels of Alpha 1 antitrypsin in Group A compared to Group B, 3.71-fold rise in Group A compared to Group C and 1.59-fold rise in Group B compared to Group C (P < 0.001). A definite rise in serum Alpha 1 antitrypsin levels in patients with oral squamous cell carcinoma as compared with healthy subjects with and without tobacco habits was observed. CONCLUSION: Alpha1-antitrypsin can be used as an adjunct to various diagnostic procedures implied for the evaluation of oral squamous cell carcinoma. Wolters Kluwer - Medknow 2019-11-15 /pmc/articles/PMC6881917/ /pubmed/31803669 http://dx.doi.org/10.4103/jfmpc.jfmpc_571_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ahuja, Upasana S.
Puri, Nidhi
Bagewadi, Anjana
Keluskar, Vaishali
Ahuja, Anshuman
Singh, Harkanwal P.
Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title_full Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title_fullStr Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title_full_unstemmed Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title_short Comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
title_sort comparative evaluation of serum alpha-1antitrypsin levels in patients with oral squamous cell carcinoma and in subjects with tobacco habit without carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881917/
https://www.ncbi.nlm.nih.gov/pubmed/31803669
http://dx.doi.org/10.4103/jfmpc.jfmpc_571_19
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