Cargando…

Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database

Osteosarcoma is predominant in the adolescent and the elderly population, but few studies have described the characteristics and prognostic factors of patients older than 60 years. In this study, the Surveillance, Epidemiology, and End Results registry database was used to identify all patients diag...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Yue, Chen, Daqi, Hu, Taobo, Lv, Guohua, Dai, Zhehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882037/
https://www.ncbi.nlm.nih.gov/pubmed/31773978
http://dx.doi.org/10.1177/1073274819888893
_version_ 1783474068020789248
author Pan, Yue
Chen, Daqi
Hu, Taobo
Lv, Guohua
Dai, Zhehao
author_facet Pan, Yue
Chen, Daqi
Hu, Taobo
Lv, Guohua
Dai, Zhehao
author_sort Pan, Yue
collection PubMed
description Osteosarcoma is predominant in the adolescent and the elderly population, but few studies have described the characteristics and prognostic factors of patients older than 60 years. In this study, the Surveillance, Epidemiology, and End Results registry database was used to identify all patients diagnosed with primary osteosarcoma from 1973 to 2014. We utilized Cox proportional hazards regression analysis to evaluate the association between patient overall survival and relevant characteristics, including gender, race, disease stage, treatment methods, primary tumor site, differentiation grade, and histologic subtype. In the data set, a total of 1139 patients with osteosarcoma older than 60 years old were identified. The overall rate of distant metastatic cases was 28.6%. Osteosarcoma occurred equally in men and women (49.5% vs 50.5%). Of all, 41.3% of tumors were located in axial location (pelvis, spine, and ribs), 34.1% of tumors were located in extremity (long or short bones of the upper or lower extremity), and 24.6% in other location (mandible, skull, and other atypical locations). Male (hazard ratio [HR] = 1.201; 95% confidence interval [CI]: 1.056-1.366), axial location (HR = 1.342; 95% CI: 1.157-1.556), distant metastasis (HR = 2.369; 95% CI: 2.015-2.785), non-surgery perform (HR = 2.108; 95% CI: 1.814-2.451) were independent risk factors for 5-year overall survival. This study revealed distinct clinicopathological features of patients with osteosarcoma older than 60 years. Male gender, tumor in axial site, nonsurgery perform, and distant metastasis indicated worse prognosis survival. Performing surgery is still an effective and reliable treatment method for patients older than 60 years.
format Online
Article
Text
id pubmed-6882037
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-68820372019-12-09 Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database Pan, Yue Chen, Daqi Hu, Taobo Lv, Guohua Dai, Zhehao Cancer Control Research Article Osteosarcoma is predominant in the adolescent and the elderly population, but few studies have described the characteristics and prognostic factors of patients older than 60 years. In this study, the Surveillance, Epidemiology, and End Results registry database was used to identify all patients diagnosed with primary osteosarcoma from 1973 to 2014. We utilized Cox proportional hazards regression analysis to evaluate the association between patient overall survival and relevant characteristics, including gender, race, disease stage, treatment methods, primary tumor site, differentiation grade, and histologic subtype. In the data set, a total of 1139 patients with osteosarcoma older than 60 years old were identified. The overall rate of distant metastatic cases was 28.6%. Osteosarcoma occurred equally in men and women (49.5% vs 50.5%). Of all, 41.3% of tumors were located in axial location (pelvis, spine, and ribs), 34.1% of tumors were located in extremity (long or short bones of the upper or lower extremity), and 24.6% in other location (mandible, skull, and other atypical locations). Male (hazard ratio [HR] = 1.201; 95% confidence interval [CI]: 1.056-1.366), axial location (HR = 1.342; 95% CI: 1.157-1.556), distant metastasis (HR = 2.369; 95% CI: 2.015-2.785), non-surgery perform (HR = 2.108; 95% CI: 1.814-2.451) were independent risk factors for 5-year overall survival. This study revealed distinct clinicopathological features of patients with osteosarcoma older than 60 years. Male gender, tumor in axial site, nonsurgery perform, and distant metastasis indicated worse prognosis survival. Performing surgery is still an effective and reliable treatment method for patients older than 60 years. SAGE Publications 2019-11-27 /pmc/articles/PMC6882037/ /pubmed/31773978 http://dx.doi.org/10.1177/1073274819888893 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Pan, Yue
Chen, Daqi
Hu, Taobo
Lv, Guohua
Dai, Zhehao
Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title_full Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title_fullStr Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title_full_unstemmed Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title_short Characteristics and Prognostic Factors of Patients With Osteosarcoma Older Than 60 Years From the SEER Database
title_sort characteristics and prognostic factors of patients with osteosarcoma older than 60 years from the seer database
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882037/
https://www.ncbi.nlm.nih.gov/pubmed/31773978
http://dx.doi.org/10.1177/1073274819888893
work_keys_str_mv AT panyue characteristicsandprognosticfactorsofpatientswithosteosarcomaolderthan60yearsfromtheseerdatabase
AT chendaqi characteristicsandprognosticfactorsofpatientswithosteosarcomaolderthan60yearsfromtheseerdatabase
AT hutaobo characteristicsandprognosticfactorsofpatientswithosteosarcomaolderthan60yearsfromtheseerdatabase
AT lvguohua characteristicsandprognosticfactorsofpatientswithosteosarcomaolderthan60yearsfromtheseerdatabase
AT daizhehao characteristicsandprognosticfactorsofpatientswithosteosarcomaolderthan60yearsfromtheseerdatabase