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Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
[Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882107/ https://www.ncbi.nlm.nih.gov/pubmed/31788627 http://dx.doi.org/10.1021/acsomega.9b02881 |
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author | Lenarda, Anna Bakandritsos, Aristides Bevilacqua, Manuela Tavagnacco, Claudio Melchionna, Michele Naldoni, Alberto Steklý, Tomáš Otyepka, Michal Zbořil, Radek Fornasiero, Paolo |
author_facet | Lenarda, Anna Bakandritsos, Aristides Bevilacqua, Manuela Tavagnacco, Claudio Melchionna, Michele Naldoni, Alberto Steklý, Tomáš Otyepka, Michal Zbořil, Radek Fornasiero, Paolo |
author_sort | Lenarda, Anna |
collection | PubMed |
description | [Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high cost, instability, complex immobilization, and inherent tendency toward denaturation of the enzyme significantly limit their practical usefulness. Inspired by the powerful proton-catalyzed H(2)O(2) reduction mechanism of peroxidases, we have developed a well-defined and densely functionalized carboxylic graphene derivative (graphene acid, GA) that serves as a proton source and conductive electrode for binding and detecting H(2)O(2). An unprecedented H(2)O(2) sensitivity of 525 μA cm(–2) mM(–1) is achieved by optimizing the balance between the carboxyl group content and scaffold conductivity of GA. Importantly, the GA sensor greatly outperforms all reported carbon-based H(2)O(2) sensors and is superior to enzymatic ones because of its simple immobilization, low cost, and uncompromised sensitivity even after continuous operation for 7 days. In addition, GA-based sensing electrodes remain highly selective in the presence of interferents such as ascorbic acid, paracetamol, and glucose, as well as complex matrices such as milk. GA-based sensors thus have considerable potential for use in practical industrial sensing technologies. |
format | Online Article Text |
id | pubmed-6882107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-68821072019-11-29 Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing Lenarda, Anna Bakandritsos, Aristides Bevilacqua, Manuela Tavagnacco, Claudio Melchionna, Michele Naldoni, Alberto Steklý, Tomáš Otyepka, Michal Zbořil, Radek Fornasiero, Paolo ACS Omega [Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high cost, instability, complex immobilization, and inherent tendency toward denaturation of the enzyme significantly limit their practical usefulness. Inspired by the powerful proton-catalyzed H(2)O(2) reduction mechanism of peroxidases, we have developed a well-defined and densely functionalized carboxylic graphene derivative (graphene acid, GA) that serves as a proton source and conductive electrode for binding and detecting H(2)O(2). An unprecedented H(2)O(2) sensitivity of 525 μA cm(–2) mM(–1) is achieved by optimizing the balance between the carboxyl group content and scaffold conductivity of GA. Importantly, the GA sensor greatly outperforms all reported carbon-based H(2)O(2) sensors and is superior to enzymatic ones because of its simple immobilization, low cost, and uncompromised sensitivity even after continuous operation for 7 days. In addition, GA-based sensing electrodes remain highly selective in the presence of interferents such as ascorbic acid, paracetamol, and glucose, as well as complex matrices such as milk. GA-based sensors thus have considerable potential for use in practical industrial sensing technologies. American Chemical Society 2019-11-15 /pmc/articles/PMC6882107/ /pubmed/31788627 http://dx.doi.org/10.1021/acsomega.9b02881 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Lenarda, Anna Bakandritsos, Aristides Bevilacqua, Manuela Tavagnacco, Claudio Melchionna, Michele Naldoni, Alberto Steklý, Tomáš Otyepka, Michal Zbořil, Radek Fornasiero, Paolo Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing |
title | Selective Functionalization
Blended with Scaffold
Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical
Sensing |
title_full | Selective Functionalization
Blended with Scaffold
Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical
Sensing |
title_fullStr | Selective Functionalization
Blended with Scaffold
Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical
Sensing |
title_full_unstemmed | Selective Functionalization
Blended with Scaffold
Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical
Sensing |
title_short | Selective Functionalization
Blended with Scaffold
Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical
Sensing |
title_sort | selective functionalization
blended with scaffold
conductivity in graphene acid promotes h(2)o(2) electrochemical
sensing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882107/ https://www.ncbi.nlm.nih.gov/pubmed/31788627 http://dx.doi.org/10.1021/acsomega.9b02881 |
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