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Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing

[Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high c...

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Autores principales: Lenarda, Anna, Bakandritsos, Aristides, Bevilacqua, Manuela, Tavagnacco, Claudio, Melchionna, Michele, Naldoni, Alberto, Steklý, Tomáš, Otyepka, Michal, Zbořil, Radek, Fornasiero, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882107/
https://www.ncbi.nlm.nih.gov/pubmed/31788627
http://dx.doi.org/10.1021/acsomega.9b02881
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author Lenarda, Anna
Bakandritsos, Aristides
Bevilacqua, Manuela
Tavagnacco, Claudio
Melchionna, Michele
Naldoni, Alberto
Steklý, Tomáš
Otyepka, Michal
Zbořil, Radek
Fornasiero, Paolo
author_facet Lenarda, Anna
Bakandritsos, Aristides
Bevilacqua, Manuela
Tavagnacco, Claudio
Melchionna, Michele
Naldoni, Alberto
Steklý, Tomáš
Otyepka, Michal
Zbořil, Radek
Fornasiero, Paolo
author_sort Lenarda, Anna
collection PubMed
description [Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high cost, instability, complex immobilization, and inherent tendency toward denaturation of the enzyme significantly limit their practical usefulness. Inspired by the powerful proton-catalyzed H(2)O(2) reduction mechanism of peroxidases, we have developed a well-defined and densely functionalized carboxylic graphene derivative (graphene acid, GA) that serves as a proton source and conductive electrode for binding and detecting H(2)O(2). An unprecedented H(2)O(2) sensitivity of 525 μA cm(–2) mM(–1) is achieved by optimizing the balance between the carboxyl group content and scaffold conductivity of GA. Importantly, the GA sensor greatly outperforms all reported carbon-based H(2)O(2) sensors and is superior to enzymatic ones because of its simple immobilization, low cost, and uncompromised sensitivity even after continuous operation for 7 days. In addition, GA-based sensing electrodes remain highly selective in the presence of interferents such as ascorbic acid, paracetamol, and glucose, as well as complex matrices such as milk. GA-based sensors thus have considerable potential for use in practical industrial sensing technologies.
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spelling pubmed-68821072019-11-29 Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing Lenarda, Anna Bakandritsos, Aristides Bevilacqua, Manuela Tavagnacco, Claudio Melchionna, Michele Naldoni, Alberto Steklý, Tomáš Otyepka, Michal Zbořil, Radek Fornasiero, Paolo ACS Omega [Image: see text] The widespread industrial use of H(2)O(2) has provoked great interest in the development of new and more efficient materials for its detection. Enzymatic electrochemical sensors have drawn particular attention, primarily because of their excellent selectivity. However, their high cost, instability, complex immobilization, and inherent tendency toward denaturation of the enzyme significantly limit their practical usefulness. Inspired by the powerful proton-catalyzed H(2)O(2) reduction mechanism of peroxidases, we have developed a well-defined and densely functionalized carboxylic graphene derivative (graphene acid, GA) that serves as a proton source and conductive electrode for binding and detecting H(2)O(2). An unprecedented H(2)O(2) sensitivity of 525 μA cm(–2) mM(–1) is achieved by optimizing the balance between the carboxyl group content and scaffold conductivity of GA. Importantly, the GA sensor greatly outperforms all reported carbon-based H(2)O(2) sensors and is superior to enzymatic ones because of its simple immobilization, low cost, and uncompromised sensitivity even after continuous operation for 7 days. In addition, GA-based sensing electrodes remain highly selective in the presence of interferents such as ascorbic acid, paracetamol, and glucose, as well as complex matrices such as milk. GA-based sensors thus have considerable potential for use in practical industrial sensing technologies. American Chemical Society 2019-11-15 /pmc/articles/PMC6882107/ /pubmed/31788627 http://dx.doi.org/10.1021/acsomega.9b02881 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Lenarda, Anna
Bakandritsos, Aristides
Bevilacqua, Manuela
Tavagnacco, Claudio
Melchionna, Michele
Naldoni, Alberto
Steklý, Tomáš
Otyepka, Michal
Zbořil, Radek
Fornasiero, Paolo
Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title_full Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title_fullStr Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title_full_unstemmed Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title_short Selective Functionalization Blended with Scaffold Conductivity in Graphene Acid Promotes H(2)O(2) Electrochemical Sensing
title_sort selective functionalization blended with scaffold conductivity in graphene acid promotes h(2)o(2) electrochemical sensing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882107/
https://www.ncbi.nlm.nih.gov/pubmed/31788627
http://dx.doi.org/10.1021/acsomega.9b02881
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