The Role of Non-Coding RNAs in Neurodevelopmental Disorders

Non-coding RNAs, a group of ribonucleic acids that are ubiquitous in the body and do not encode proteins, emerge as important regulatory factors in almost all biological processes in the brain. Extensive studies have suggested the involvement of non-coding RNAs in brain development and neurodevelopm...

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Autores principales: Zhang, Shuang-Feng, Gao, Jun, Liu, Chang-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882276/
https://www.ncbi.nlm.nih.gov/pubmed/31824553
http://dx.doi.org/10.3389/fgene.2019.01033
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author Zhang, Shuang-Feng
Gao, Jun
Liu, Chang-Mei
author_facet Zhang, Shuang-Feng
Gao, Jun
Liu, Chang-Mei
author_sort Zhang, Shuang-Feng
collection PubMed
description Non-coding RNAs, a group of ribonucleic acids that are ubiquitous in the body and do not encode proteins, emerge as important regulatory factors in almost all biological processes in the brain. Extensive studies have suggested the involvement of non-coding RNAs in brain development and neurodevelopmental disorders, and dysregulation of non-coding RNAs is associated with abnormal brain development and the etiology of neurodevelopmental disorders. Here we provide an overview of the roles and working mechanisms of non-coding RNAs, and discuss potential clinical applications of non-coding RNAs as diagnostic and prognostic markers and as therapeutic targets in neurodevelopmental disorders.
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spelling pubmed-68822762019-12-10 The Role of Non-Coding RNAs in Neurodevelopmental Disorders Zhang, Shuang-Feng Gao, Jun Liu, Chang-Mei Front Genet Genetics Non-coding RNAs, a group of ribonucleic acids that are ubiquitous in the body and do not encode proteins, emerge as important regulatory factors in almost all biological processes in the brain. Extensive studies have suggested the involvement of non-coding RNAs in brain development and neurodevelopmental disorders, and dysregulation of non-coding RNAs is associated with abnormal brain development and the etiology of neurodevelopmental disorders. Here we provide an overview of the roles and working mechanisms of non-coding RNAs, and discuss potential clinical applications of non-coding RNAs as diagnostic and prognostic markers and as therapeutic targets in neurodevelopmental disorders. Frontiers Media S.A. 2019-11-20 /pmc/articles/PMC6882276/ /pubmed/31824553 http://dx.doi.org/10.3389/fgene.2019.01033 Text en Copyright © 2019 Zhang, Gao and Liu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhang, Shuang-Feng
Gao, Jun
Liu, Chang-Mei
The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title_full The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title_fullStr The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title_full_unstemmed The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title_short The Role of Non-Coding RNAs in Neurodevelopmental Disorders
title_sort role of non-coding rnas in neurodevelopmental disorders
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882276/
https://www.ncbi.nlm.nih.gov/pubmed/31824553
http://dx.doi.org/10.3389/fgene.2019.01033
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