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The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study
BACKGROUND: Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the risk of dental caries decreases with the use of pilocarpine in patients with p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882320/ https://www.ncbi.nlm.nih.gov/pubmed/31775834 http://dx.doi.org/10.1186/s13075-019-2031-7 |
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author | Hsu, Chung-Yuan Hung, Kuo-Chun Lin, Ming-Shyan Ko, Chi-Hua Lin, Yu-Sheng Chen, Tien-Hsing Lin, Chun-Yu Chen, Ying-Chou |
author_facet | Hsu, Chung-Yuan Hung, Kuo-Chun Lin, Ming-Shyan Ko, Chi-Hua Lin, Yu-Sheng Chen, Tien-Hsing Lin, Chun-Yu Chen, Ying-Chou |
author_sort | Hsu, Chung-Yuan |
collection | PubMed |
description | BACKGROUND: Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the risk of dental caries decreases with the use of pilocarpine in patients with pSS. METHODS: For this prospective cohort study, we identified pSS patients from the catastrophic illnesses registry of the National Health Insurance Research Database of Taiwan between 2009 and 2013. We divided participants into pilocarpine and non-user groups based on the pilocarpine prescriptions available during the first 3-month follow-up. The primary endpoint was dental caries. The secondary endpoints were periodontitis and oral candidiasis. We compared the risk of these oral manifestations using the Cox proportional hazard model. RESULTS: A total of 4973 patients with new-onset pSS were eligible for analysis. After propensity score matching, we included 1014 patients in the pilocarpine group and 2028 patients in the non-user group. During the mean follow-up of 2.6 years, the number of events was 487 in the pilocarpine group (48.0%) and 1047 in the non-user group (51.6%); however, the difference was not significant (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.82 to 1.06). Furthermore, there was no significant difference between groups regarding risk of periodontitis (HR 0.91, 95% CI 0.81 to 1.03) and oral candidiasis (HR 1.16, 95% CI 0.70 to 1.94). CONCLUSION: Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS. |
format | Online Article Text |
id | pubmed-6882320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68823202019-12-03 The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study Hsu, Chung-Yuan Hung, Kuo-Chun Lin, Ming-Shyan Ko, Chi-Hua Lin, Yu-Sheng Chen, Tien-Hsing Lin, Chun-Yu Chen, Ying-Chou Arthritis Res Ther Research Article BACKGROUND: Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the risk of dental caries decreases with the use of pilocarpine in patients with pSS. METHODS: For this prospective cohort study, we identified pSS patients from the catastrophic illnesses registry of the National Health Insurance Research Database of Taiwan between 2009 and 2013. We divided participants into pilocarpine and non-user groups based on the pilocarpine prescriptions available during the first 3-month follow-up. The primary endpoint was dental caries. The secondary endpoints were periodontitis and oral candidiasis. We compared the risk of these oral manifestations using the Cox proportional hazard model. RESULTS: A total of 4973 patients with new-onset pSS were eligible for analysis. After propensity score matching, we included 1014 patients in the pilocarpine group and 2028 patients in the non-user group. During the mean follow-up of 2.6 years, the number of events was 487 in the pilocarpine group (48.0%) and 1047 in the non-user group (51.6%); however, the difference was not significant (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.82 to 1.06). Furthermore, there was no significant difference between groups regarding risk of periodontitis (HR 0.91, 95% CI 0.81 to 1.03) and oral candidiasis (HR 1.16, 95% CI 0.70 to 1.94). CONCLUSION: Pilocarpine may have no protective effect on dental caries, periodontitis, or oral candidiasis in patients with pSS. BioMed Central 2019-11-27 2019 /pmc/articles/PMC6882320/ /pubmed/31775834 http://dx.doi.org/10.1186/s13075-019-2031-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Hsu, Chung-Yuan Hung, Kuo-Chun Lin, Ming-Shyan Ko, Chi-Hua Lin, Yu-Sheng Chen, Tien-Hsing Lin, Chun-Yu Chen, Ying-Chou The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title | The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title_full | The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title_fullStr | The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title_full_unstemmed | The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title_short | The effect of pilocarpine on dental caries in patients with primary Sjögren’s syndrome: a database prospective cohort study |
title_sort | effect of pilocarpine on dental caries in patients with primary sjögren’s syndrome: a database prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882320/ https://www.ncbi.nlm.nih.gov/pubmed/31775834 http://dx.doi.org/10.1186/s13075-019-2031-7 |
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