Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents

Twenty novel talmapimod analogues were designed, synthesised and evaluated for the in vivo anti-inflammatory activities. Among them, compound 6n, the most potent one, was selected for exploring the mechanisms underlying its anti-inflammatory efficacy. In RAW264.7 cells, it effectively suppressed lip...

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Detalles Bibliográficos
Autores principales: Liu, Wandong, Hou, Caiyun, Li, Jiaming, Ma, Xiaodong, Zhang, Yanchun, Hu, Mengqi, Huang, Yuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882468/
https://www.ncbi.nlm.nih.gov/pubmed/31752552
http://dx.doi.org/10.1080/14756366.2019.1693703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882468/
https://www.ncbi.nlm.nih.gov/pubmed/31752552
http://dx.doi.org/10.1080/14756366.2019.1693703

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