Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLIF) pharmacophore and docking was utilised for scre...

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Detalles Bibliográficos
Autores principales: Liang, Jing-Wei, Wang, Ming-Yang, Wang, Shan, Li, Shi-Long, Li, Wan-Qiu, Meng, Fan-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882486/
https://www.ncbi.nlm.nih.gov/pubmed/31760818
http://dx.doi.org/10.1080/14756366.2019.1693702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882486/
https://www.ncbi.nlm.nih.gov/pubmed/31760818
http://dx.doi.org/10.1080/14756366.2019.1693702

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