Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopa...

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Autores principales: Xia, Huan, Guan, Yuanlin, Zaongo, Silvère D., Xia, Han, Wang, Ziyu, Yan, Zhongfang, Ma, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882502/
https://www.ncbi.nlm.nih.gov/pubmed/31824396
http://dx.doi.org/10.3389/fneur.2019.01202
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author Xia, Huan
Guan, Yuanlin
Zaongo, Silvère D.
Xia, Han
Wang, Ziyu
Yan, Zhongfang
Ma, Ping
author_facet Xia, Huan
Guan, Yuanlin
Zaongo, Silvère D.
Xia, Han
Wang, Ziyu
Yan, Zhongfang
Ma, Ping
author_sort Xia, Huan
collection PubMed
description Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).
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spelling pubmed-68825022019-12-10 Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient Xia, Huan Guan, Yuanlin Zaongo, Silvère D. Xia, Han Wang, Ziyu Yan, Zhongfang Ma, Ping Front Neurol Neurology Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML). Frontiers Media S.A. 2019-11-21 /pmc/articles/PMC6882502/ /pubmed/31824396 http://dx.doi.org/10.3389/fneur.2019.01202 Text en Copyright © 2019 Xia, Guan, Zaongo, Xia, Wang, Yan and Ma. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Xia, Huan
Guan, Yuanlin
Zaongo, Silvère D.
Xia, Han
Wang, Ziyu
Yan, Zhongfang
Ma, Ping
Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_full Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_fullStr Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_full_unstemmed Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_short Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_sort progressive multifocal leukoencephalopathy diagnosed by metagenomic next-generation sequencing of cerebrospinal fluid in an hiv patient
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882502/
https://www.ncbi.nlm.nih.gov/pubmed/31824396
http://dx.doi.org/10.3389/fneur.2019.01202
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