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Elevating acetyl-CoA levels reduces aspects of brain aging

Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121 and J147, were used to identify a unique...

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Detalles Bibliográficos
Autores principales:	Currais, Antonio, Huang, Ling, Goldberg, Joshua, Petrascheck, Michael, Ates, Gamze, Pinto-Duarte, António, Shokhirev, Maxim N, Schubert, David, Maher, Pamela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882557/ https://www.ncbi.nlm.nih.gov/pubmed/31742554 http://dx.doi.org/10.7554/eLife.47866

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