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High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model

High-mobility group box-1 (HMGB1) is a nuclear protein that promotes inflammation during the acute phase post-stroke, and enhances angiogenesis during the delayed phase. Here, we evaluated whether indirect revascularization surgery with HMGB1 accelerates brain angiogenesis in a chronic cerebral hypo...

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Autores principales: Nishihiro, Shingo, Hishikawa, Tomohito, Hiramatsu, Masafumi, Kidani, Naoya, Takahashi, Yu, Murai, Satoshi, Sugiu, Kenji, Higaki, Yusuke, Yasuhara, Takao, Borlongan, Cesario V., Date, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882763/
https://www.ncbi.nlm.nih.gov/pubmed/31123914
http://dx.doi.org/10.1007/s12017-019-08541-x
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author Nishihiro, Shingo
Hishikawa, Tomohito
Hiramatsu, Masafumi
Kidani, Naoya
Takahashi, Yu
Murai, Satoshi
Sugiu, Kenji
Higaki, Yusuke
Yasuhara, Takao
Borlongan, Cesario V.
Date, Isao
author_facet Nishihiro, Shingo
Hishikawa, Tomohito
Hiramatsu, Masafumi
Kidani, Naoya
Takahashi, Yu
Murai, Satoshi
Sugiu, Kenji
Higaki, Yusuke
Yasuhara, Takao
Borlongan, Cesario V.
Date, Isao
author_sort Nishihiro, Shingo
collection PubMed
description High-mobility group box-1 (HMGB1) is a nuclear protein that promotes inflammation during the acute phase post-stroke, and enhances angiogenesis during the delayed phase. Here, we evaluated whether indirect revascularization surgery with HMGB1 accelerates brain angiogenesis in a chronic cerebral hypoperfusion model. Seven days after hypoperfusion induction, encephalo-myo-synangiosis (EMS) was performed with or without HMGB1 treatment into the temporal muscle. We detected significant increments in cortical vasculature (p < 0.01), vascular endothelial growth factor (VEGF) expression in the temporal muscle (p < 0.05), and ratio of radiation intensity on the operated side compared with the non-operated side after EMS in the HMGB1-treated group than in the control group (p < 0.01). Altogether, HMGB1 with EMS in a chronic hypoperfusion model promoted brain angiogenesis in a VEGF-dependent manner, resulting in cerebral blood flow improvement. This treatment may be an effective therapy for patients with moyamoya disease.
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spelling pubmed-68827632019-12-12 High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model Nishihiro, Shingo Hishikawa, Tomohito Hiramatsu, Masafumi Kidani, Naoya Takahashi, Yu Murai, Satoshi Sugiu, Kenji Higaki, Yusuke Yasuhara, Takao Borlongan, Cesario V. Date, Isao Neuromolecular Med Original Paper High-mobility group box-1 (HMGB1) is a nuclear protein that promotes inflammation during the acute phase post-stroke, and enhances angiogenesis during the delayed phase. Here, we evaluated whether indirect revascularization surgery with HMGB1 accelerates brain angiogenesis in a chronic cerebral hypoperfusion model. Seven days after hypoperfusion induction, encephalo-myo-synangiosis (EMS) was performed with or without HMGB1 treatment into the temporal muscle. We detected significant increments in cortical vasculature (p < 0.01), vascular endothelial growth factor (VEGF) expression in the temporal muscle (p < 0.05), and ratio of radiation intensity on the operated side compared with the non-operated side after EMS in the HMGB1-treated group than in the control group (p < 0.01). Altogether, HMGB1 with EMS in a chronic hypoperfusion model promoted brain angiogenesis in a VEGF-dependent manner, resulting in cerebral blood flow improvement. This treatment may be an effective therapy for patients with moyamoya disease. Springer US 2019-05-23 2019 /pmc/articles/PMC6882763/ /pubmed/31123914 http://dx.doi.org/10.1007/s12017-019-08541-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Nishihiro, Shingo
Hishikawa, Tomohito
Hiramatsu, Masafumi
Kidani, Naoya
Takahashi, Yu
Murai, Satoshi
Sugiu, Kenji
Higaki, Yusuke
Yasuhara, Takao
Borlongan, Cesario V.
Date, Isao
High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title_full High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title_fullStr High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title_full_unstemmed High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title_short High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model
title_sort high-mobility group box-1-induced angiogenesis after indirect bypass surgery in a chronic cerebral hypoperfusion model
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882763/
https://www.ncbi.nlm.nih.gov/pubmed/31123914
http://dx.doi.org/10.1007/s12017-019-08541-x
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