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Characterization of genetic subclonal evolution in pancreatic cancer mouse models

The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model recapitulates the subclonal evolution of this tumor type is unknown. Here we report evidence of continuing subclonal evol...

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Detalles Bibliográficos
Autores principales:	Niknafs, Noushin, Zhong, Yi, Moral, John Alec, Zhang, Lance, Shao, Melody Xiaoshan, Lo, April, Makohon-Moore, Alvin, Iacobuzio-Donahue, Christine A., Karchin, Rachel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882784/ https://www.ncbi.nlm.nih.gov/pubmed/31780749 http://dx.doi.org/10.1038/s41467-019-13100-w

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