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Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC)...

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Autores principales: Luo, Yanmin, Xiao, Qian, Wang, Jin, Jiang, Lin, Hu, Menglan, Jiang, Yanhong, Tang, Jing, Liang, Xin, Qi, Yingqiang, Dou, Xiaoyun, Zhang, Yi, Huang, Chunxia, Chen, Linmu, Tang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882819/
https://www.ncbi.nlm.nih.gov/pubmed/31780641
http://dx.doi.org/10.1038/s41398-019-0662-8
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author Luo, Yanmin
Xiao, Qian
Wang, Jin
Jiang, Lin
Hu, Menglan
Jiang, Yanhong
Tang, Jing
Liang, Xin
Qi, Yingqiang
Dou, Xiaoyun
Zhang, Yi
Huang, Chunxia
Chen, Linmu
Tang, Yong
author_facet Luo, Yanmin
Xiao, Qian
Wang, Jin
Jiang, Lin
Hu, Menglan
Jiang, Yanhong
Tang, Jing
Liang, Xin
Qi, Yingqiang
Dou, Xiaoyun
Zhang, Yi
Huang, Chunxia
Chen, Linmu
Tang, Yong
author_sort Luo, Yanmin
collection PubMed
description Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase(+) oligodendrocytes and Olig2(+) oligodendrocytes, reduced the ratio between Olig2(+)/NG2(+) oligodendrocytes and Olig2(+) oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2(+) oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.
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spelling pubmed-68828192019-12-06 Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model Luo, Yanmin Xiao, Qian Wang, Jin Jiang, Lin Hu, Menglan Jiang, Yanhong Tang, Jing Liang, Xin Qi, Yingqiang Dou, Xiaoyun Zhang, Yi Huang, Chunxia Chen, Linmu Tang, Yong Transl Psychiatry Article Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase(+) oligodendrocytes and Olig2(+) oligodendrocytes, reduced the ratio between Olig2(+)/NG2(+) oligodendrocytes and Olig2(+) oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2(+) oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise. Nature Publishing Group UK 2019-11-28 /pmc/articles/PMC6882819/ /pubmed/31780641 http://dx.doi.org/10.1038/s41398-019-0662-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Luo, Yanmin
Xiao, Qian
Wang, Jin
Jiang, Lin
Hu, Menglan
Jiang, Yanhong
Tang, Jing
Liang, Xin
Qi, Yingqiang
Dou, Xiaoyun
Zhang, Yi
Huang, Chunxia
Chen, Linmu
Tang, Yong
Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title_full Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title_fullStr Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title_full_unstemmed Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title_short Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
title_sort running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882819/
https://www.ncbi.nlm.nih.gov/pubmed/31780641
http://dx.doi.org/10.1038/s41398-019-0662-8
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