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Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4
Insulin-like peptide 5 (INSL5) is a very important pharma target for treating human conditions such as anorexia and diabetes. However, INSL5 with two chains and three disulfide bridges is an extremely difficult peptide to assemble by chemical or recombinant means. In a recent study, we were able to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882824/ https://www.ncbi.nlm.nih.gov/pubmed/31780677 http://dx.doi.org/10.1038/s41598-019-53707-z |