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µ-opioid receptor-mediated downregulation of midline thalamic pathways to basal and central amygdala

Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR e...

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Detalles Bibliográficos
Autores principales: Goedecke, L., Bengoetxea, X., Blaesse, P., Pape, H.-C., Jüngling, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882837/
https://www.ncbi.nlm.nih.gov/pubmed/31780740
http://dx.doi.org/10.1038/s41598-019-54128-8