Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFα-induction of neutral-sphingomyelinase2 (nSMase2) to release p...

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Detalles Bibliográficos
Autores principales: Arcidiacono, Maria Vittoria, Carrillo-López, Natalia, Panizo, Sara, Castro-Grattoni, Anabel L., Valcheva, Petya, Ulloa, Catalina, Rodríguez-Carrio, Javier, Cardús, Anna, Quirós-Caso, Covadonga, Martínez-Arias, Laura, Martínez-Salgado, Carlos, Motilva, María José, Rodriguez-Suarez, Carmen, Cannata-Andía, Jorge B., Dusso, Adriana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882851/
https://www.ncbi.nlm.nih.gov/pubmed/31780737
http://dx.doi.org/10.1038/s41598-019-54306-8

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