Cargando…
Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice
Synaptic inhibition plays a fundamental role in the information processing of neural circuits. It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these essential functions, dysregulated synaptic inhibition causes a plethora of neurological disorders, including epilepsy...
Autores principales: | Kim, Hye Yun, Yang, Yong Ryoul, Hwang, Hongik, Lee, Ha-Eun, Jang, Hyun-Jun, Kim, Jeongyeon, Yang, Esther, Kim, Hyun, Rhim, Hyewhon, Suh, Pann-Ghill, Kim, Jae-Ick |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882884/ https://www.ncbi.nlm.nih.gov/pubmed/31780806 http://dx.doi.org/10.1038/s41598-019-54477-4 |
Ejemplares similares
-
Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus
por: Kim, Sunpil, et al.
Publicado: (2022) -
The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy
por: Kim, Hye Yun, et al.
Publicado: (2021) -
PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III
por: Kim, Hye Yun, et al.
Publicado: (2023) -
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
por: Yang, Yong Ryoul, et al.
Publicado: (2017) -
Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation
por: Hong, Joohyeon, et al.
Publicado: (2020)