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Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats

Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental...

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Autores principales: Napso, Tina, Hung, Yin-Po, Davidge, Sandra T., Care, Alison S., Sferruzzi-Perri, Amanda N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882885/
https://www.ncbi.nlm.nih.gov/pubmed/31780670
http://dx.doi.org/10.1038/s41598-019-53199-x
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author Napso, Tina
Hung, Yin-Po
Davidge, Sandra T.
Care, Alison S.
Sferruzzi-Perri, Amanda N.
author_facet Napso, Tina
Hung, Yin-Po
Davidge, Sandra T.
Care, Alison S.
Sferruzzi-Perri, Amanda N.
author_sort Napso, Tina
collection PubMed
description Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3–4 months) dams, advanced maternal age (9.5–10 months) compromises growth of both female and male fetuses but affects the placental phenotype sex-specifically. In placentas from aged versus young dams, the size of the placental transport and endocrine zones were increased and expression of Igf2 (+41%) and placental lactogen (Prl3b1: +59%) genes were upregulated in female, but not male fetuses. Placental abundance of IGF2 protein also decreased in the placenta of males only (−95%). Moreover, in placentas from aged versus young dams, glucocorticoid metabolism (11β-hsd2: +63% and 11β-hsd1: −33%) was higher in females, but lower in males (11β-hsd2: −50% and 11β-hsd1: unaltered). There was however, no change in the placental abundance of 11β-HSD2 protein in aged versus young dams regardless of fetal sex. Levels of oxidative stress in the placenta were increased in female and male fetuses (+57% and +90%, respectively) and apoptosis increased specifically in the placenta of males from aged rat dams (+700%). Thus, advanced maternal age alters placental phenotype in a sex-specific fashion. These sexually-divergent changes may play a role in determining health outcomes of female and male offspring of aged mothers.
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spelling pubmed-68828852019-12-06 Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats Napso, Tina Hung, Yin-Po Davidge, Sandra T. Care, Alison S. Sferruzzi-Perri, Amanda N. Sci Rep Article Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3–4 months) dams, advanced maternal age (9.5–10 months) compromises growth of both female and male fetuses but affects the placental phenotype sex-specifically. In placentas from aged versus young dams, the size of the placental transport and endocrine zones were increased and expression of Igf2 (+41%) and placental lactogen (Prl3b1: +59%) genes were upregulated in female, but not male fetuses. Placental abundance of IGF2 protein also decreased in the placenta of males only (−95%). Moreover, in placentas from aged versus young dams, glucocorticoid metabolism (11β-hsd2: +63% and 11β-hsd1: −33%) was higher in females, but lower in males (11β-hsd2: −50% and 11β-hsd1: unaltered). There was however, no change in the placental abundance of 11β-HSD2 protein in aged versus young dams regardless of fetal sex. Levels of oxidative stress in the placenta were increased in female and male fetuses (+57% and +90%, respectively) and apoptosis increased specifically in the placenta of males from aged rat dams (+700%). Thus, advanced maternal age alters placental phenotype in a sex-specific fashion. These sexually-divergent changes may play a role in determining health outcomes of female and male offspring of aged mothers. Nature Publishing Group UK 2019-11-28 /pmc/articles/PMC6882885/ /pubmed/31780670 http://dx.doi.org/10.1038/s41598-019-53199-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Napso, Tina
Hung, Yin-Po
Davidge, Sandra T.
Care, Alison S.
Sferruzzi-Perri, Amanda N.
Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title_full Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title_fullStr Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title_full_unstemmed Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title_short Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
title_sort advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882885/
https://www.ncbi.nlm.nih.gov/pubmed/31780670
http://dx.doi.org/10.1038/s41598-019-53199-x
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