PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 (PCDH17) gene was frequently methylated and functioned as a...

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Detalles Bibliográficos
Autores principales: Liu, Shuiping, Lin, Haoming, Wang, Da, Li, Qiang, Luo, Hong, Li, Guoxiong, Chen, Xiaohui, Li, Yongqiang, Chen, Peng, Zhai, Bingtao, Wang, Wengang, Zhang, Ruonan, Chen, Bi, Zhang, Mingming, Han, Xuemeng, Li, Qiujie, Chen, Liuxi, Liu, Ying, Chen, Xiaying, Li, Guohua, Xiang, Yu, Duan, Ting, Feng, Jiao, Lou, Jianshu, Huang, Xingxing, Zhang, Qin, Pan, Ting, Yan, Lili, Jin, Ting, Zhang, Wenzheng, Zhuo, Lvjia, Sun, Yitian, Xie, Tian, Sui, Xinbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882894/
https://www.ncbi.nlm.nih.gov/pubmed/31815010
http://dx.doi.org/10.1038/s41392-019-0087-0

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