Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden

Monozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and...

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Detalles Bibliográficos
Autores principales: Silva, Susana L., Fonseca, Mariana, Pereira, Marcelo L. M., Silva, Sara P., Barbosa, Rita R., Serra-Caetano, Ana, Blanco, Elena, Rosmaninho, Pedro, Pérez-Andrés, Martin, Sousa, Ana Berta, Raposo, Alexandre A. S. F., Gama-Carvalho, Margarida, Victorino, Rui M. M., Hammarstrom, Lennart, Sousa, Ana E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882918/
https://www.ncbi.nlm.nih.gov/pubmed/31824477
http://dx.doi.org/10.3389/fimmu.2019.02503

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