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Filiform polyposis with sigmoid colon adenocarcinoma: a case report

BACKGROUND: Filiform polyposis is a rare form of inflammatory polyposis, which is occasionally formed in the colon of patients with history of inflammatory bowel disease (IBD). It is characterized by presence of several to hundreds of slender, worm-like polyps in the colon lined by histologically no...

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Autores principales: Okuno, Takayuki, Kanazawa, Takamitsu, Kishi, Hirohisa, Anzai, Hiroyuki, Yasuda, Koji, Ishihara, Soichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883011/
https://www.ncbi.nlm.nih.gov/pubmed/31782007
http://dx.doi.org/10.1186/s40792-019-0747-x
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author Okuno, Takayuki
Kanazawa, Takamitsu
Kishi, Hirohisa
Anzai, Hiroyuki
Yasuda, Koji
Ishihara, Soichiro
author_facet Okuno, Takayuki
Kanazawa, Takamitsu
Kishi, Hirohisa
Anzai, Hiroyuki
Yasuda, Koji
Ishihara, Soichiro
author_sort Okuno, Takayuki
collection PubMed
description BACKGROUND: Filiform polyposis is a rare form of inflammatory polyposis, which is occasionally formed in the colon of patients with history of inflammatory bowel disease (IBD). It is characterized by presence of several to hundreds of slender, worm-like polyps in the colon lined by histologically normal colonic mucosa and often coalesce, resulting in a tumor-like mass. Filiform polyposis is most frequently associated with a post-inflammatory reparative process in patients with IBD history, and only cases of filiform polyposis occurring in patients without IBD history have been reported. Filiform polyposis has been considered as a benign inflammatory polyposis without any risk of dysplasia, while the possibility of carcinogenesis of inflammatory polyps is not fully excluded. To date, only three cases of filiform polyposis coexisting with dysplasia have been reported. CASE PRESENTATION: A 59-year-old male patient with no past medical history of IBD underwent laparoscopic sigmoidectomy for obstructive filiform polyposis, which was associated with sigmoid colon adenocarcinoma. Based on the histological findings of the resected specimen, invasive sigmoid colon adenocarcinoma was surrounded by filiform polyposis, and adenocarcinoma also scattered uniformly on the surface of filiform polyposis. In immunohistochemistry, abnormal p53 expression was observed in adenocarcinoma, while it was not shown in mucosa on filiform polyposis. CONCLUSIONS: This is the fourth case of filiform polyposis that is closely associated with colon dysplasia or adenocarcinoma based on histological findings. However, immunohistochemical findings did not support the theory that inflammation initiates adenocarcinoma in filiform polyposis like IBD. Hence, further immunohistochemical and genetic analyses are needed to clarify the association between filiform polyposis and carcinogenesis.
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spelling pubmed-68830112019-12-12 Filiform polyposis with sigmoid colon adenocarcinoma: a case report Okuno, Takayuki Kanazawa, Takamitsu Kishi, Hirohisa Anzai, Hiroyuki Yasuda, Koji Ishihara, Soichiro Surg Case Rep Case Report BACKGROUND: Filiform polyposis is a rare form of inflammatory polyposis, which is occasionally formed in the colon of patients with history of inflammatory bowel disease (IBD). It is characterized by presence of several to hundreds of slender, worm-like polyps in the colon lined by histologically normal colonic mucosa and often coalesce, resulting in a tumor-like mass. Filiform polyposis is most frequently associated with a post-inflammatory reparative process in patients with IBD history, and only cases of filiform polyposis occurring in patients without IBD history have been reported. Filiform polyposis has been considered as a benign inflammatory polyposis without any risk of dysplasia, while the possibility of carcinogenesis of inflammatory polyps is not fully excluded. To date, only three cases of filiform polyposis coexisting with dysplasia have been reported. CASE PRESENTATION: A 59-year-old male patient with no past medical history of IBD underwent laparoscopic sigmoidectomy for obstructive filiform polyposis, which was associated with sigmoid colon adenocarcinoma. Based on the histological findings of the resected specimen, invasive sigmoid colon adenocarcinoma was surrounded by filiform polyposis, and adenocarcinoma also scattered uniformly on the surface of filiform polyposis. In immunohistochemistry, abnormal p53 expression was observed in adenocarcinoma, while it was not shown in mucosa on filiform polyposis. CONCLUSIONS: This is the fourth case of filiform polyposis that is closely associated with colon dysplasia or adenocarcinoma based on histological findings. However, immunohistochemical findings did not support the theory that inflammation initiates adenocarcinoma in filiform polyposis like IBD. Hence, further immunohistochemical and genetic analyses are needed to clarify the association between filiform polyposis and carcinogenesis. Springer Berlin Heidelberg 2019-11-28 /pmc/articles/PMC6883011/ /pubmed/31782007 http://dx.doi.org/10.1186/s40792-019-0747-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Okuno, Takayuki
Kanazawa, Takamitsu
Kishi, Hirohisa
Anzai, Hiroyuki
Yasuda, Koji
Ishihara, Soichiro
Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title_full Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title_fullStr Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title_full_unstemmed Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title_short Filiform polyposis with sigmoid colon adenocarcinoma: a case report
title_sort filiform polyposis with sigmoid colon adenocarcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883011/
https://www.ncbi.nlm.nih.gov/pubmed/31782007
http://dx.doi.org/10.1186/s40792-019-0747-x
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