An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

Live attenuated vaccines (LAVs) are one of the most important strategies to control flavivirus diseases. The flavivirus nonstructural (NS) 4B proteins are a critical component of both the virus replication complex and evasion of host innate immunity. Here we have used site-directed mutagenesis of re...

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Detalles Bibliográficos
Autores principales: Li, Guangyu, Adam, Awadalkareem, Luo, Huanle, Shan, Chao, Cao, Zengguo, Fontes-Garfias, Camila R., Sarathy, Vanessa V., Teleki, Cody, Winkelmann, Evandro R., Liang, Yuejin, Sun, Jiaren, Bourne, Nigel, Barrett, Alan D. T., Shi, Pei-Yong, Wang, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883050/
https://www.ncbi.nlm.nih.gov/pubmed/31815005
http://dx.doi.org/10.1038/s41541-019-0143-3

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