Cargando…

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

The identification of biomarkers that discriminate individual ageing trajectories is a principal target of ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks age-related phenotypes in addition to c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stevenson, Anna J., McCartney, Daniel L., Hillary, Robert F., Redmond, Paul, Taylor, Adele M., Zhang, Qian, McRae, Allan F., Spires-Jones, Tara L., McIntosh, Andrew M., Deary, Ian J., Marioni, Riccardo E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883059/ https://www.ncbi.nlm.nih.gov/pubmed/31780646 http://dx.doi.org/10.1038/s41398-019-0657-5

Ejemplares similares

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing
por: Stevenson, Anna J., et al.
Publicado: (2018)

Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6
por: Stevenson, Anna J, et al.
Publicado: (2021)

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability
por: Stevenson, Anna J., et al.
Publicado: (2020)

DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
por: Seeboth, Anne, et al.
Publicado: (2020)

A comparison of blood and brain‐derived ageing and inflammation‐related DNA methylation signatures and their association with microglial burdens
por: Stevenson, Anna J., et al.
Publicado: (2022)

Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design
por: Hillary, Robert F., et al.
Publicado: (2022)

Integration of datasets for individual prediction of DNA methylation-based biomarkers
por: Merzbacher, Charlotte, et al.
Publicado: (2023)

An epigenetic predictor of death captures multi-modal measures of brain health
por: Hillary, Robert F., et al.
Publicado: (2019)

Epigenetic predictors of lifestyle traits applied to the blood and brain
por: Gadd, Danni A, et al.
Publicado: (2021)

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
por: Hillary, Robert F., et al.
Publicado: (2020)

Epigenetic prediction of complex traits and death
por: McCartney, Daniel L., et al.
Publicado: (2018)

An epigenome-wide association study of sex-specific chronological ageing
por: McCartney, Daniel L., et al.
Publicado: (2019)

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
por: Hillary, Robert F., et al.
Publicado: (2019)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
por: Hamilton, Olivia K. L., et al.
Publicado: (2019)

Birth weight associations with DNA methylation differences in an adult population
por: Madden, Rebecca A., et al.
Publicado: (2020)

DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health
por: Mur, Jure, et al.
Publicado: (2020)

Epigenetic signatures of starting and stopping smoking
por: McCartney, Daniel L., et al.
Publicado: (2018)

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
por: McCartney, Daniel L., et al.
Publicado: (2018)

Childhood cognitive ability and self-harm and suicide in later life
por: Iveson, Matthew H., et al.
Publicado: (2023)

Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults
por: Hillary, Robert F., et al.
Publicado: (2020)

Genome‐ and epigenome‐wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk
por: Hillary, Robert F., et al.
Publicado: (2022)

Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits
por: Banos, Daniel Trejo, et al.
Publicado: (2020)

Bayesian reassessment of the epigenetic architecture of complex traits
por: Trejo Banos, Daniel, et al.
Publicado: (2020)

Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936
por: Iveson, Matthew H., et al.
Publicado: (2022)

Epigenetic scores for the circulating proteome as tools for disease prediction
por: Gadd, Danni A, et al.
Publicado: (2022)

Correction: Epigenetic scores for the circulating proteome as tools for disease prediction
por: Gadd, Danni A, et al.
Publicado: (2023)

Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
por: Hillary, Robert F., et al.
Publicado: (2023)

Genotype effects contribute to variation in longitudinal methylome patterns in older people
por: Zhang, Qian, et al.
Publicado: (2018)

Relationship between childhood socioeconomic position and adverse childhood experiences (ACEs): a systematic review
por: Walsh, David, et al.
Publicado: (2019)

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
por: Hill, W. D., et al.
Publicado: (2018)

The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer’s disease
por: A Gadd, Danni, et al.
Publicado: (2022)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2016)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2018)

Lateral Approach and Plate Rod Sliding Humeral Osteotomy in Dogs—A Short Case Series
por: McCartney, William, et al.
Publicado: (2023)

Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip
por: McCartney, Daniel L., et al.
Publicado: (2016)

Refining epigenetic prediction of chronological and biological age
por: Bernabeu, Elena, et al.
Publicado: (2023)

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
por: Marioni, Riccardo E, et al.
Publicado: (2015)

Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait
por: Chundru, V. Kartik, et al.
Publicado: (2019)

Early-life predictors of resilience and related outcomes up to 66 years later in the 6-day sample of the 1947 Scottish mental survey
por: Harris, Mathew A., et al.
Publicado: (2016)

Is there a link between childhood adversity, attachment style and Scotland’s excess mortality? Evidence, challenges and potential research
por: Smith, M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qkh9gluhpbp2ihnld8ajq4un1m