Cargando…

Unraveling Determinants of Affinity Enhancement in Dimeric Aptamers for a Dimeric Protein

High-affinity aptamers can be derived de novo by using stringent conditions in SELEX (Systematic Evolution of Ligands by EXponential enrichment) experiments or can be engineered post SELEX via dimerization of selected aptamers. Using electrophoretic mobility shift assays, we studied a series of hete...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manochehry, Sepehr, McConnell, Erin M., Li, Yingfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883073/ https://www.ncbi.nlm.nih.gov/pubmed/31780794 http://dx.doi.org/10.1038/s41598-019-54005-4

Ejemplares similares

Improvement of Aptamer Affinity by Dimerization
por: Hasegawa, Hijiri, et al.
Publicado: (2008)

Colorimetric Detection of Uranyl Using a Litmus Test
por: Manochehry, Sepehr, et al.
Publicado: (2018)

Aptamer-Based Biosensors for Environmental Monitoring
por: McConnell, Erin M., et al.
Publicado: (2020)

Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition
por: Riccardi, Claudia, et al.
Publicado: (2020)

High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva
por: Zhang, Zijie, et al.
Publicado: (2021)

Inter-protein residue covariation information unravels physically interacting protein dimers
por: Salmanian, Sara, et al.
Publicado: (2020)

Nerve Targeting via Myelin Protein Zero and the Impact of Dimerization on Binding Affinity
por: Berehova, Nataliia, et al.
Publicado: (2022)

Impact of Differential Detergent Interactions on Transmembrane Helix Dimerization Affinities
por: Qureshi, Tabussom, et al.
Publicado: (2016)

A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice
por: Nagano, Masanobu, et al.
Publicado: (2023)

Molecular Insight into Affinities of Gallated and Nongallated Proanthocyanidins Dimers to Lipid Bilayers
por: Zhu, Wei, et al.
Publicado: (2016)

First Principles Calculation of Protein–Protein Dimer Affinities of ALS-Associated SOD1 Mutants
por: Hsueh, Shawn C. C., et al.
Publicado: (2022)

Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography
por: Platonova, Natalia, et al.
Publicado: (2014)

Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy
por: Ruff, Karen M., et al.
Publicado: (2014)

A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells
por: Bouhedda, Farah, et al.
Publicado: (2019)

Conserved determinants of lentiviral genome dimerization
por: Tran, Thao, et al.
Publicado: (2015)

GR Dimerization and the Impact of GR Dimerization on GR Protein Stability and Half-Life
por: Louw, Ann
Publicado: (2019)

Robo1 Forms a Compact Dimer-of-Dimers Assembly
por: Aleksandrova, Nataliia, et al.
Publicado: (2018)

A general model for predicting the binding affinity of reversibly and irreversibly dimerized ligands
por: Foreman, Kenneth W.
Publicado: (2017)

Dimerization in protein kinase signaling
por: Pelech, Steven
Publicado: (2006)

Dimerization of Transmembrane Proteins in Cancer Immunotherapy
por: Li, Lei, et al.
Publicado: (2023)

Enhanced Chiral Recognition by Cyclodextrin Dimers
por: Voskuhl, Jens, et al.
Publicado: (2011)

Hepatitis B virus core protein dimer-dimer interface is critical for viral replication
por: Zheng, Chang-Long, et al.
Publicado: (2019)

Dimers and Orientifolds
por: Franco, Sebastian, et al.
Publicado: (2007)

Admission D-dimer levels, D-dimer trends, and outcomes in COVID-19
por: Naymagon, Leonard, et al.
Publicado: (2020)

Development of a Monomeric Inhibitory RNA Aptamer Specific for FGFR3 that Acts as an Activator When Dimerized
por: Kamatkar, Nachiket, et al.
Publicado: (2019)

FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion
por: Harada, Masayo, et al.
Publicado: (2009)

A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein
por: Khatri, Bhavesh, et al.
Publicado: (2022)

Annihilator dimers enhance triplet fusion upconversion
por: Pun, Andrew B., et al.
Publicado: (2019)

Dimer–dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba
por: Jelinska, Clare, et al.
Publicado: (2010)

ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment
por: Tišma, Miloš, et al.
Publicado: (2022)

Triangular lattice quantum dimer model with variable dimer density
por: Yan, Zheng, et al.
Publicado: (2022)

Formation of Cystine Slipknots in Dimeric Proteins
por: Sikora, Mateusz, et al.
Publicado: (2013)

End Binding Proteins Are Obligatory Dimers
por: Sen, Indrani, et al.
Publicado: (2013)

Linking in domain-swapped protein dimers
por: Baiesi, Marco, et al.
Publicado: (2016)

Dimerization of Neuronal Calcium Sensor Proteins
por: Ames, James B.
Publicado: (2018)

Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence
por: Heintz, Udo, et al.
Publicado: (2016)

Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics
por: Hanold, Laura E., et al.
Publicado: (2015)

Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs
por: Riccardi, Claudia, et al.
Publicado: (2020)

Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments
por: Cruz-Toledo, Jose, et al.
Publicado: (2012)

Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
por: Kessler, Dirk, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7q53m53nb9abd7mlvc5ioe88f3