PKCα is required for Akt-mTORC1 activation in Non-Small Cell Lung Carcinoma (NSCLC) with EGFR mutation

Mutational activation of the epidermal growth factor receptor (EGFR) is a major player in the pathogenesis of non-small cell lung cancer (NSCLC). NSCLC patients with constitutively active EGFR mutations (mEGFR) eventually develop drug resistance against EGFR tyrosine-kinase inhibitors (TKIs); theref...

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Detalles Bibliográficos
Autores principales: Salama, Mohamed F., Liu, Mengling, Clarke, Christopher J., Espaillat, Mel Pilar, Haley, John, Jin, Ting, Wang, Daifeng, Obeid, Lina M., Hannun, Yusuf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883150/
https://www.ncbi.nlm.nih.gov/pubmed/31420605
http://dx.doi.org/10.1038/s41388-019-0950-z

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