Long-term seizure freedom following intracranial sEEG monitoring: Therapeutic benefit of a diagnostic technique

Patients with treatment-resistant epilepsy often require surgery. It is very rare that patients with TRE can have sustained seizure freedom spontaneously, without undergoing further resection or neuro-modulation after invasive monitoring with sEEG. Of the 78 TRE cases monitored over last 5 years, we identified three patients who became seizure-free following sEEG monitoring without undergoing further resection or neuro-modulation. Seizure-freedom after sEEG is possible even without further intervention. In cases where seizures after the completion of the invasive monitoring are not observed, a longer observation period following electrode explantation prior to planned neuro-modulation or resection is warranted. This could be due to the disruption of the cortical–subcortical epileptogenic network due to focal area of tissue damage along and around the electrode tract.