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Glutamine deprivation counteracts hypoxia-induced chemoresistance
The microenvironment of solid tumors is a key determinant of therapy efficacy. The co-occurrence of oxygen and nutrient deprivation is a common phenomenon of the tumor microenvironment and associated with treatment resistance. Cholangiocarcinoma (CCA) is characterized by a very poor prognosis and pr...
Autores principales: | Wappler, Jessica, Arts, Martijn, Röth, Anjali, Heeren, Ron M.A., Peter Neumann, Ulf, Olde Damink, Steven W., Soons, Zita, Cramer, Thorsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883317/ https://www.ncbi.nlm.nih.gov/pubmed/31765939 http://dx.doi.org/10.1016/j.neo.2019.10.004 |
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