Cargando…

Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)

This article describes isolation and pancreatic lipase (PL) inhibitory potential of 18 endophytic fungi isolated from the various parts of six indigenous medicinal plants. PL catalyzes absorption and hydrolysis of triglycerides into di-glycerides into mono-glycerides and free fatty acids. PL inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Patil, Mohini P., Patil, Ravindra H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883320/
https://www.ncbi.nlm.nih.gov/pubmed/31799348
http://dx.doi.org/10.1016/j.dib.2019.104797
_version_ 1783474356125433856
author Patil, Mohini P.
Patil, Ravindra H.
author_facet Patil, Mohini P.
Patil, Ravindra H.
author_sort Patil, Mohini P.
collection PubMed
description This article describes isolation and pancreatic lipase (PL) inhibitory potential of 18 endophytic fungi isolated from the various parts of six indigenous medicinal plants. PL catalyzes absorption and hydrolysis of triglycerides into di-glycerides into mono-glycerides and free fatty acids. PL inhibitors are well-known for the disruption of pancreatic lipase activity. The quest for novel pancreatic lipase inhibitors is crucially important owing to their therapeutic potential in the treatment of obesity and related chronic diseases. The present dataset provides information about the presence of endophytic fungi in the internal tissues of selected plants and the PL inhibitory potential of their metabolites using bioassay based screening. Absence of the yellow zone surrounding the standard Orlistat and test extract indicated PL inhibition due to the cumulative effect of metabolites present in the extract. The data suggests that TLC bio-autographic method is simple, rapid and reproducible and therefore it could be effectively used for high throughput screening of PL inhibitors from natural sources.
format Online
Article
Text
id pubmed-6883320
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-68833202019-12-03 Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL) Patil, Mohini P. Patil, Ravindra H. Data Brief Biochemistry, Genetics and Molecular Biology This article describes isolation and pancreatic lipase (PL) inhibitory potential of 18 endophytic fungi isolated from the various parts of six indigenous medicinal plants. PL catalyzes absorption and hydrolysis of triglycerides into di-glycerides into mono-glycerides and free fatty acids. PL inhibitors are well-known for the disruption of pancreatic lipase activity. The quest for novel pancreatic lipase inhibitors is crucially important owing to their therapeutic potential in the treatment of obesity and related chronic diseases. The present dataset provides information about the presence of endophytic fungi in the internal tissues of selected plants and the PL inhibitory potential of their metabolites using bioassay based screening. Absence of the yellow zone surrounding the standard Orlistat and test extract indicated PL inhibition due to the cumulative effect of metabolites present in the extract. The data suggests that TLC bio-autographic method is simple, rapid and reproducible and therefore it could be effectively used for high throughput screening of PL inhibitors from natural sources. Elsevier 2019-11-13 /pmc/articles/PMC6883320/ /pubmed/31799348 http://dx.doi.org/10.1016/j.dib.2019.104797 Text en © 2019 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Patil, Mohini P.
Patil, Ravindra H.
Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title_full Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title_fullStr Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title_full_unstemmed Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title_short Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL)
title_sort data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (pl)
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883320/
https://www.ncbi.nlm.nih.gov/pubmed/31799348
http://dx.doi.org/10.1016/j.dib.2019.104797
work_keys_str_mv AT patilmohinip dataontheinhibitoryeffectofendophyticfungioftraditionalmedicinalplantsagainstpancreaticlipasepl
AT patilravindrah dataontheinhibitoryeffectofendophyticfungioftraditionalmedicinalplantsagainstpancreaticlipasepl