Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show that mutant β-catenin can be transported via extracellular vesicles (EVs) and activate Wnt signalling pathway in the recipient cells. An integrative proteogenomic analysis...

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Detalles Bibliográficos
Autores principales: Kalra, Hina, Gangoda, Lahiru, Fonseka, Pamali, Chitti, Sai V., Liem, Michael, Keerthikumar, Shivakumar, Samuel, Monisha, Boukouris, Stephanie, Al Saffar, Haidar, Collins, Christine, Adda, Christopher G., Ang, Ching-Seng, Mathivanan, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883417/
https://www.ncbi.nlm.nih.gov/pubmed/31819794
http://dx.doi.org/10.1080/20013078.2019.1690217

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