Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection

HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment t...

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Detalles Bibliográficos
Autores principales: Liu, Xinlin, Chen, Jie, Wang, Zhiping, Wang, Daning, He, Maozhou, Qian, Ciying, Song, Shuo, Chi, Xin, Kong, Zhibo, Zheng, Qingbing, Wang, Yingbin, Yu, Hai, Zhao, Qinjian, Zhang, Jun, Li, Shaowei, Gu, Ying, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883418/
https://www.ncbi.nlm.nih.gov/pubmed/31769733
http://dx.doi.org/10.1080/22221751.2019.1694396
Descripción
Sumario:HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface.

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