Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection

HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment t...

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Autores principales: Liu, Xinlin, Chen, Jie, Wang, Zhiping, Wang, Daning, He, Maozhou, Qian, Ciying, Song, Shuo, Chi, Xin, Kong, Zhibo, Zheng, Qingbing, Wang, Yingbin, Yu, Hai, Zhao, Qinjian, Zhang, Jun, Li, Shaowei, Gu, Ying, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883418/
https://www.ncbi.nlm.nih.gov/pubmed/31769733
http://dx.doi.org/10.1080/22221751.2019.1694396
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author Liu, Xinlin
Chen, Jie
Wang, Zhiping
Wang, Daning
He, Maozhou
Qian, Ciying
Song, Shuo
Chi, Xin
Kong, Zhibo
Zheng, Qingbing
Wang, Yingbin
Yu, Hai
Zhao, Qinjian
Zhang, Jun
Li, Shaowei
Gu, Ying
Xia, Ningshao
author_facet Liu, Xinlin
Chen, Jie
Wang, Zhiping
Wang, Daning
He, Maozhou
Qian, Ciying
Song, Shuo
Chi, Xin
Kong, Zhibo
Zheng, Qingbing
Wang, Yingbin
Yu, Hai
Zhao, Qinjian
Zhang, Jun
Li, Shaowei
Gu, Ying
Xia, Ningshao
author_sort Liu, Xinlin
collection PubMed
description HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface.
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spelling pubmed-68834182019-12-09 Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection Liu, Xinlin Chen, Jie Wang, Zhiping Wang, Daning He, Maozhou Qian, Ciying Song, Shuo Chi, Xin Kong, Zhibo Zheng, Qingbing Wang, Yingbin Yu, Hai Zhao, Qinjian Zhang, Jun Li, Shaowei Gu, Ying Xia, Ningshao Emerg Microbes Infect Original Articles HIGHLIGHTS: Major neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structure; mAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralization; mAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface. Taylor & Francis 2019-11-26 /pmc/articles/PMC6883418/ /pubmed/31769733 http://dx.doi.org/10.1080/22221751.2019.1694396 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Liu, Xinlin
Chen, Jie
Wang, Zhiping
Wang, Daning
He, Maozhou
Qian, Ciying
Song, Shuo
Chi, Xin
Kong, Zhibo
Zheng, Qingbing
Wang, Yingbin
Yu, Hai
Zhao, Qinjian
Zhang, Jun
Li, Shaowei
Gu, Ying
Xia, Ningshao
Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title_full Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title_fullStr Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title_full_unstemmed Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title_short Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
title_sort neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883418/
https://www.ncbi.nlm.nih.gov/pubmed/31769733
http://dx.doi.org/10.1080/22221751.2019.1694396
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