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Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite

BACKGROUND: Snakebite envenomation is a major public health problem in the developing world, and the effects of viper envenomation on renal tissues leading to acute kidney injury (AKI) are well known. However, the usefulness of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker to dete...

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Autores principales: Senthilkumaran, Subramanian, Thirumalaikolundusubramanian, Ponniah, Elangovan, Namasivayam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883503/
https://www.ncbi.nlm.nih.gov/pubmed/31798239
http://dx.doi.org/10.4103/JETS.JETS_32_18
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author Senthilkumaran, Subramanian
Thirumalaikolundusubramanian, Ponniah
Elangovan, Namasivayam
author_facet Senthilkumaran, Subramanian
Thirumalaikolundusubramanian, Ponniah
Elangovan, Namasivayam
author_sort Senthilkumaran, Subramanian
collection PubMed
description BACKGROUND: Snakebite envenomation is a major public health problem in the developing world, and the effects of viper envenomation on renal tissues leading to acute kidney injury (AKI) are well known. However, the usefulness of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker to detect AKI in viper envenomation cases were not studied much. AIMS AND OBJECTIVES: The present study was undertaken to find out plasma NGAL levels and assess its usefulness among the hospitalized Viperidae group of snakebite victims in predicting acute kidney injury. MATERIALS AND METHODS: The plasma NGAL level was estimated within 6–8 h of all the 184 cases of viper bites along with other laboratory parameters. RESULTS: It was elevated much before the elevation of serum creatinine levels, irrespective of the age, gender, and bite to hospital time. The sensitivity and specificity was 99.37 and 96.15, respectively. Elevated plasma NGAL levels in viper bite helped not only to detect AKI early but also assisted to plan for appropriate intervention. CONCLUSION: It is suggested to include estimation of plasma NGAL in the point of care testing, especially in emergency settings handling snakebite cases. However, more studies are recommended to find out its serial levels in snakebite cases following different kinds of snake envenomation with different clinical and laboratory manifestations in different age groups and gender belonging to different population so as to arrive at valid conclusions.
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spelling pubmed-68835032019-12-03 Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite Senthilkumaran, Subramanian Thirumalaikolundusubramanian, Ponniah Elangovan, Namasivayam J Emerg Trauma Shock Original Research Paper BACKGROUND: Snakebite envenomation is a major public health problem in the developing world, and the effects of viper envenomation on renal tissues leading to acute kidney injury (AKI) are well known. However, the usefulness of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker to detect AKI in viper envenomation cases were not studied much. AIMS AND OBJECTIVES: The present study was undertaken to find out plasma NGAL levels and assess its usefulness among the hospitalized Viperidae group of snakebite victims in predicting acute kidney injury. MATERIALS AND METHODS: The plasma NGAL level was estimated within 6–8 h of all the 184 cases of viper bites along with other laboratory parameters. RESULTS: It was elevated much before the elevation of serum creatinine levels, irrespective of the age, gender, and bite to hospital time. The sensitivity and specificity was 99.37 and 96.15, respectively. Elevated plasma NGAL levels in viper bite helped not only to detect AKI early but also assisted to plan for appropriate intervention. CONCLUSION: It is suggested to include estimation of plasma NGAL in the point of care testing, especially in emergency settings handling snakebite cases. However, more studies are recommended to find out its serial levels in snakebite cases following different kinds of snake envenomation with different clinical and laboratory manifestations in different age groups and gender belonging to different population so as to arrive at valid conclusions. Wolters Kluwer - Medknow 2019 2019-11-18 /pmc/articles/PMC6883503/ /pubmed/31798239 http://dx.doi.org/10.4103/JETS.JETS_32_18 Text en Copyright: © 2019 Journal of Emergencies, Trauma, and Shock http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Research Paper
Senthilkumaran, Subramanian
Thirumalaikolundusubramanian, Ponniah
Elangovan, Namasivayam
Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title_full Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title_fullStr Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title_full_unstemmed Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title_short Neutrophil Gelatinase-Associated Lipocalin as an Early Diagnostic Biomarker of Acute Kidney Injury in Snake Bite
title_sort neutrophil gelatinase-associated lipocalin as an early diagnostic biomarker of acute kidney injury in snake bite
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883503/
https://www.ncbi.nlm.nih.gov/pubmed/31798239
http://dx.doi.org/10.4103/JETS.JETS_32_18
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