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Meningitis gone viral: description of the echovirus wave 2013 in Germany
BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differen...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883514/ https://www.ncbi.nlm.nih.gov/pubmed/31783807 http://dx.doi.org/10.1186/s12879-019-4635-6 |
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author | Graf, Jonas Hartmann, Christian J. Lehmann, Helmar C. Otto, Carolin Adams, Ortwin Karenfort, Michael Schneider, Christian Ruprecht, Klemens Bosse, Hans Martin Diedrich, Sabine Böttcher, Sindy Schnitzler, Alfons Hartung, Hans-Peter Aktas, Orhan Albrecht, Philipp |
author_facet | Graf, Jonas Hartmann, Christian J. Lehmann, Helmar C. Otto, Carolin Adams, Ortwin Karenfort, Michael Schneider, Christian Ruprecht, Klemens Bosse, Hans Martin Diedrich, Sabine Böttcher, Sindy Schnitzler, Alfons Hartung, Hans-Peter Aktas, Orhan Albrecht, Philipp |
author_sort | Graf, Jonas |
collection | PubMed |
description | BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and 1 EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. CONCLUSIONS: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases. |
format | Online Article Text |
id | pubmed-6883514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68835142019-12-03 Meningitis gone viral: description of the echovirus wave 2013 in Germany Graf, Jonas Hartmann, Christian J. Lehmann, Helmar C. Otto, Carolin Adams, Ortwin Karenfort, Michael Schneider, Christian Ruprecht, Klemens Bosse, Hans Martin Diedrich, Sabine Böttcher, Sindy Schnitzler, Alfons Hartung, Hans-Peter Aktas, Orhan Albrecht, Philipp BMC Infect Dis Research Article BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and 1 EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. CONCLUSIONS: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases. BioMed Central 2019-11-29 /pmc/articles/PMC6883514/ /pubmed/31783807 http://dx.doi.org/10.1186/s12879-019-4635-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Graf, Jonas Hartmann, Christian J. Lehmann, Helmar C. Otto, Carolin Adams, Ortwin Karenfort, Michael Schneider, Christian Ruprecht, Klemens Bosse, Hans Martin Diedrich, Sabine Böttcher, Sindy Schnitzler, Alfons Hartung, Hans-Peter Aktas, Orhan Albrecht, Philipp Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title | Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title_full | Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title_fullStr | Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title_full_unstemmed | Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title_short | Meningitis gone viral: description of the echovirus wave 2013 in Germany |
title_sort | meningitis gone viral: description of the echovirus wave 2013 in germany |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883514/ https://www.ncbi.nlm.nih.gov/pubmed/31783807 http://dx.doi.org/10.1186/s12879-019-4635-6 |
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