Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

BACKGROUND: Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (T(N)) and central memory (T(CM)) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tumor effects. To optimize the maintenance of such populations during the...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres Chavez, Alejandro, McKenna, Mary Kathryn, Canestrari, Emanuele, Dann, Christina T., Ramos, Carlos A., Lulla, Premal, Leen, Ann M., Vera, Juan F., Watanabe, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883585/
https://www.ncbi.nlm.nih.gov/pubmed/31779709
http://dx.doi.org/10.1186/s40425-019-0804-9

Ejemplares similares

Ejemplares similares