Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2

BACKGROUND: The degenerative disc disease (DDD) is a major cause of low back pain. The physiological low-glucose microenvironment of the cartilage endplate (CEP) is disrupted in DDD. Glucose influences protein O-GlcNAcylation via the hexosamine biosynthetic pathway (HBP), which is the key to stem ce...

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Detalles Bibliográficos
Autores principales: Sun, Chao, Lan, Weiren, Li, Bin, Zuo, Rui, Xing, Hui, Liu, Minghan, Li, Jie, Yao, Yuan, Wu, Junlong, Tang, Yu, Liu, Huan, Zhou, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883626/
https://www.ncbi.nlm.nih.gov/pubmed/31779679
http://dx.doi.org/10.1186/s13287-019-1440-5

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