Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by...

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Autores principales: Qiu, Guanguan, Zheng, Guoping, Ge, Menghua, Wang, Jiangmei, Huang, Ruoqiong, Shu, Qiang, Xu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883709/
https://www.ncbi.nlm.nih.gov/pubmed/31779700
http://dx.doi.org/10.1186/s13287-019-1484-6
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author Qiu, Guanguan
Zheng, Guoping
Ge, Menghua
Wang, Jiangmei
Huang, Ruoqiong
Shu, Qiang
Xu, Jianguo
author_facet Qiu, Guanguan
Zheng, Guoping
Ge, Menghua
Wang, Jiangmei
Huang, Ruoqiong
Shu, Qiang
Xu, Jianguo
author_sort Qiu, Guanguan
collection PubMed
description Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.
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spelling pubmed-68837092019-12-03 Functional proteins of mesenchymal stem cell-derived extracellular vesicles Qiu, Guanguan Zheng, Guoping Ge, Menghua Wang, Jiangmei Huang, Ruoqiong Shu, Qiang Xu, Jianguo Stem Cell Res Ther Review Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs. BioMed Central 2019-11-28 /pmc/articles/PMC6883709/ /pubmed/31779700 http://dx.doi.org/10.1186/s13287-019-1484-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Qiu, Guanguan
Zheng, Guoping
Ge, Menghua
Wang, Jiangmei
Huang, Ruoqiong
Shu, Qiang
Xu, Jianguo
Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title_full Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title_fullStr Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title_full_unstemmed Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title_short Functional proteins of mesenchymal stem cell-derived extracellular vesicles
title_sort functional proteins of mesenchymal stem cell-derived extracellular vesicles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883709/
https://www.ncbi.nlm.nih.gov/pubmed/31779700
http://dx.doi.org/10.1186/s13287-019-1484-6
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