Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Supercentenarians, people who have reached 110 y of age, are a great model of healthy aging. Their characteristics of delayed onset of age-related diseases and compression of morbidity imply that their immune system remains functional. Here we performed single-cell transcriptome analysis of 61,202 p...

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Detalles Bibliográficos
Autores principales: Hashimoto, Kosuke, Kouno, Tsukasa, Ikawa, Tomokatsu, Hayatsu, Norihito, Miyajima, Yurina, Yabukami, Haruka, Terooatea, Tommy, Sasaki, Takashi, Suzuki, Takahiro, Valentine, Matthew, Pascarella, Giovanni, Okazaki, Yasushi, Suzuki, Harukazu, Shin, Jay W., Minoda, Aki, Taniuchi, Ichiro, Okano, Hideyuki, Arai, Yasumichi, Hirose, Nobuyoshi, Carninci, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883788/
https://www.ncbi.nlm.nih.gov/pubmed/31719197
http://dx.doi.org/10.1073/pnas.1907883116

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