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Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease
To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory status of the circuits at the time they are producing the behavior. Such knowledge...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883794/ https://www.ncbi.nlm.nih.gov/pubmed/31712414 http://dx.doi.org/10.1073/pnas.1912128116 |
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author | Chopek, Jeremy W. Hultborn, Hans Brownstone, Robert M. |
author_facet | Chopek, Jeremy W. Hultborn, Hans Brownstone, Robert M. |
author_sort | Chopek, Jeremy W. |
collection | PubMed |
description | To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory status of the circuits at the time they are producing the behavior. Such knowledge of human neural circuits is difficult, at best, to obtain. Here, we study firing properties of human subthalamic neurons, using microelectrode recordings and microstimulation during awake surgery for Parkinson’s disease. We demonstrate that low-amplitude, brief trains of microstimulation can lead to persistent changes in neuronal firing behavior including switching between firing rates, entering silent periods, or firing several bursts then entering a silent period. We suggest that these multistable states reflect properties of finite state machines and could have implications for the function of circuits involving the subthalamic nucleus. Furthermore, understanding these states could lead to therapeutic strategies aimed at regulating the transitions between states. |
format | Online Article Text |
id | pubmed-6883794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-68837942019-12-04 Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease Chopek, Jeremy W. Hultborn, Hans Brownstone, Robert M. Proc Natl Acad Sci U S A Biological Sciences To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory status of the circuits at the time they are producing the behavior. Such knowledge of human neural circuits is difficult, at best, to obtain. Here, we study firing properties of human subthalamic neurons, using microelectrode recordings and microstimulation during awake surgery for Parkinson’s disease. We demonstrate that low-amplitude, brief trains of microstimulation can lead to persistent changes in neuronal firing behavior including switching between firing rates, entering silent periods, or firing several bursts then entering a silent period. We suggest that these multistable states reflect properties of finite state machines and could have implications for the function of circuits involving the subthalamic nucleus. Furthermore, understanding these states could lead to therapeutic strategies aimed at regulating the transitions between states. National Academy of Sciences 2019-11-26 2019-11-11 /pmc/articles/PMC6883794/ /pubmed/31712414 http://dx.doi.org/10.1073/pnas.1912128116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Chopek, Jeremy W. Hultborn, Hans Brownstone, Robert M. Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title | Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title_full | Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title_fullStr | Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title_full_unstemmed | Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title_short | Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease |
title_sort | multistable properties of human subthalamic nucleus neurons in parkinson’s disease |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883794/ https://www.ncbi.nlm.nih.gov/pubmed/31712414 http://dx.doi.org/10.1073/pnas.1912128116 |
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