Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review

Granulomatosis with polyangiitis (GPA) commonly affects upper/lower respiratory tract and kidneys. It causes necrotizing vasculitis of small and medium-sized blood vessels. Gastrointestinal (GI) involvement is an uncommon manifestation of GPA, and presentation with predominant GI manifestation is no...

Descripción completa

Detalles Bibliográficos
Autores principales: Bagai, Sahil, Sharma, Aman, Gupta, Rajesh, Kumar, Vivek, Rathi, Manish, Kohli, Harbir S., Gupta, Krishan L., Ramachandran, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883856/
https://www.ncbi.nlm.nih.gov/pubmed/31798224
http://dx.doi.org/10.4103/ijn.IJN_141_18
Descripción
Sumario:Granulomatosis with polyangiitis (GPA) commonly affects upper/lower respiratory tract and kidneys. It causes necrotizing vasculitis of small and medium-sized blood vessels. Gastrointestinal (GI) involvement is an uncommon manifestation of GPA, and presentation with predominant GI manifestation is noteworthy. We report a case of 50-year-old male with melena due to GI vasculitis along with other systemic involvement. The patient was treated with pulse methylprednisolone, cyclophosphamide, and plasmapheresis. To manage the refractory GI bleed, the patient underwent surgical resection, and the histology of the surgical specimen confirmed necrotizing vasculitis.

Ejemplares similares