Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review

Granulomatosis with polyangiitis (GPA) commonly affects upper/lower respiratory tract and kidneys. It causes necrotizing vasculitis of small and medium-sized blood vessels. Gastrointestinal (GI) involvement is an uncommon manifestation of GPA, and presentation with predominant GI manifestation is no...

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Autores principales: Bagai, Sahil, Sharma, Aman, Gupta, Rajesh, Kumar, Vivek, Rathi, Manish, Kohli, Harbir S., Gupta, Krishan L., Ramachandran, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883856/
https://www.ncbi.nlm.nih.gov/pubmed/31798224
http://dx.doi.org/10.4103/ijn.IJN_141_18
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author Bagai, Sahil
Sharma, Aman
Gupta, Rajesh
Kumar, Vivek
Rathi, Manish
Kohli, Harbir S.
Gupta, Krishan L.
Ramachandran, Raja
author_facet Bagai, Sahil
Sharma, Aman
Gupta, Rajesh
Kumar, Vivek
Rathi, Manish
Kohli, Harbir S.
Gupta, Krishan L.
Ramachandran, Raja
author_sort Bagai, Sahil
collection PubMed
description Granulomatosis with polyangiitis (GPA) commonly affects upper/lower respiratory tract and kidneys. It causes necrotizing vasculitis of small and medium-sized blood vessels. Gastrointestinal (GI) involvement is an uncommon manifestation of GPA, and presentation with predominant GI manifestation is noteworthy. We report a case of 50-year-old male with melena due to GI vasculitis along with other systemic involvement. The patient was treated with pulse methylprednisolone, cyclophosphamide, and plasmapheresis. To manage the refractory GI bleed, the patient underwent surgical resection, and the histology of the surgical specimen confirmed necrotizing vasculitis.
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spelling pubmed-68838562019-12-03 Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review Bagai, Sahil Sharma, Aman Gupta, Rajesh Kumar, Vivek Rathi, Manish Kohli, Harbir S. Gupta, Krishan L. Ramachandran, Raja Indian J Nephrol Case Report Granulomatosis with polyangiitis (GPA) commonly affects upper/lower respiratory tract and kidneys. It causes necrotizing vasculitis of small and medium-sized blood vessels. Gastrointestinal (GI) involvement is an uncommon manifestation of GPA, and presentation with predominant GI manifestation is noteworthy. We report a case of 50-year-old male with melena due to GI vasculitis along with other systemic involvement. The patient was treated with pulse methylprednisolone, cyclophosphamide, and plasmapheresis. To manage the refractory GI bleed, the patient underwent surgical resection, and the histology of the surgical specimen confirmed necrotizing vasculitis. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6883856/ /pubmed/31798224 http://dx.doi.org/10.4103/ijn.IJN_141_18 Text en Copyright: © 2019 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Bagai, Sahil
Sharma, Aman
Gupta, Rajesh
Kumar, Vivek
Rathi, Manish
Kohli, Harbir S.
Gupta, Krishan L.
Ramachandran, Raja
Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title_full Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title_fullStr Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title_full_unstemmed Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title_short Gastrointestinal Involvement in Granulomatosis with Polyangiitis: Case Report and Review
title_sort gastrointestinal involvement in granulomatosis with polyangiitis: case report and review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883856/
https://www.ncbi.nlm.nih.gov/pubmed/31798224
http://dx.doi.org/10.4103/ijn.IJN_141_18
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