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Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin

As one of the common neurological diseases, pediatric middle fossa arachnoid cysts(MFACs) can develop intracystic hemorrhage and subdural hematoma. Risk factors for pediatric arachnoid cyst rupture/hemorrhage is very complicated in mechanism. Although surgery is the first choice for children with MF...

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Autores principales: Liu, Bei, Wang, Chao, Qu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884023/
https://www.ncbi.nlm.nih.gov/pubmed/31824309
http://dx.doi.org/10.3389/fphar.2019.01343
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author Liu, Bei
Wang, Chao
Qu, Yan
author_facet Liu, Bei
Wang, Chao
Qu, Yan
author_sort Liu, Bei
collection PubMed
description As one of the common neurological diseases, pediatric middle fossa arachnoid cysts(MFACs) can develop intracystic hemorrhage and subdural hematoma. Risk factors for pediatric arachnoid cyst rupture/hemorrhage is very complicated in mechanism. Although surgery is the first choice for children with MFACs and subdural hematoma, the rate of recurrence of the subdural hematoma is very high after 1 or more surgeries. Atorvastatin has proven to be a bold and safe choice in the management of subdural hematoma with mild symptoms. The present study has described a 7-year-old child with a recurrent rupture of arachnoid cyst develops into a subdural hematoma. We demonstrate that atorvastatin is safe and effective in pediatric patient who has failed surgical treatment of middle fossa arachnoid cyst and subdural hematoma. The patient received atorvastatin monotherapy, once daily for the first week, with an initial dose of 5 mg, followed by 10 mg once daily for 7 weeks. In the third month after the initial treatment, the neurological function recovered, and the hematoma completely resolved. This case report supports the concept that atorvastatin can promote the absorption of subdural hematoma.
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spelling pubmed-68840232019-12-10 Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin Liu, Bei Wang, Chao Qu, Yan Front Pharmacol Pharmacology As one of the common neurological diseases, pediatric middle fossa arachnoid cysts(MFACs) can develop intracystic hemorrhage and subdural hematoma. Risk factors for pediatric arachnoid cyst rupture/hemorrhage is very complicated in mechanism. Although surgery is the first choice for children with MFACs and subdural hematoma, the rate of recurrence of the subdural hematoma is very high after 1 or more surgeries. Atorvastatin has proven to be a bold and safe choice in the management of subdural hematoma with mild symptoms. The present study has described a 7-year-old child with a recurrent rupture of arachnoid cyst develops into a subdural hematoma. We demonstrate that atorvastatin is safe and effective in pediatric patient who has failed surgical treatment of middle fossa arachnoid cyst and subdural hematoma. The patient received atorvastatin monotherapy, once daily for the first week, with an initial dose of 5 mg, followed by 10 mg once daily for 7 weeks. In the third month after the initial treatment, the neurological function recovered, and the hematoma completely resolved. This case report supports the concept that atorvastatin can promote the absorption of subdural hematoma. Frontiers Media S.A. 2019-11-22 /pmc/articles/PMC6884023/ /pubmed/31824309 http://dx.doi.org/10.3389/fphar.2019.01343 Text en Copyright © 2019 Liu, Wang and Qu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Bei
Wang, Chao
Qu, Yan
Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title_full Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title_fullStr Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title_full_unstemmed Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title_short Treatment of Arachnoid Cyst With Spontaneous Hemorrhage With Atorvastatin
title_sort treatment of arachnoid cyst with spontaneous hemorrhage with atorvastatin
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884023/
https://www.ncbi.nlm.nih.gov/pubmed/31824309
http://dx.doi.org/10.3389/fphar.2019.01343
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